INT143464

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.57
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb)
plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Anatomy Link Frequency
respiratory 2
Cybb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 7 100.00 Very High Very High Very High
depression 6 96.12 Very High Very High Very High
anesthesia 1 91.72 High High
Central nervous system 1 79.52 Quite High
fibrosis 1 75.80 Quite High
Pain 1 70.84 Quite High
Inflammation 2 65.80 Quite High
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 98.56 Very High Very High Very High
Neutrophil Disorders 79 97.76 Very High Very High Very High
Depression 2 96.12 Very High Very High Very High
Heart Rate Under Development 1 95.48 Very High Very High Very High
Pressure Volume 2 Under Development 1 94.96 High High
Cardiovascular Disorder Under Development 4 84.80 Quite High
Fibrosis 1 75.80 Quite High
Granuloma 5 68.16 Quite High
INFLAMMATION 2 65.80 Quite High
Infection 14 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in the gp91phox gene (CYBB on chromosome Xp21.1) cause the X-linked recessive form of the disease that affects the majority of CGD patients (?
Positive_regulation (cause) of Positive_regulation (Mutations) of CYBB associated with disease and neutrophil disorders
1) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668749 Disease Relevance 1.01 Pain Relevance 0.18
This was accompanied by an increase in O2*- production (60-240 min) in the RVLM, alongside phosphorylation of p47(phox) or p67(phox), upregulation of gp91(phox) or p47(phox) protein, and increase in Rac-1 or NADPH oxidase activity (60-120 min), and a depression of mitochondrial respiratory enzyme activity (120-240 min).
Positive_regulation (increase) of Positive_regulation (upregulation) of gp91 in respiratory associated with rostral ventrolateral medulla and depression
2) Confidence 0.01 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17448908 Disease Relevance 0.56 Pain Relevance 0.55

General Comments

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