INT143466

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.67
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb)
plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Anatomy Link Frequency
immune cells 1
aorta 1
respiratory 1
Cybb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 7 98.90 Very High Very High Very High
depression 6 96.12 Very High Very High Very High
anesthesia 7 87.44 High High
cerebral cortex 2 82.80 Quite High
Hippocampus 17 81.84 Quite High
Central nervous system 1 79.52 Quite High
fibrosis 3 75.80 Quite High
Inflammation 6 73.12 Quite High
Pain 1 70.84 Quite High
ischemia 86 50.00 Quite Low
Disease Link Frequency Relevance Heat
Neutrophil Disorders 79 97.76 Very High Very High Very High
Stress 34 97.44 Very High Very High Very High
Disease 18 97.44 Very High Very High Very High
Depression 2 96.12 Very High Very High Very High
Heart Rate Under Development 1 91.20 High High
Pressure Volume 2 Under Development 1 90.68 High High
Targeted Disruption 3 90.12 High High
Stroke 9 87.28 High High
Death 26 86.60 High High
Cardiovascular Disorder Under Development 8 80.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in immune cells have provided evidence that the Rho GTPase, Rac1, plays an important role in NOX2 activation in immune cells.
Positive_regulation (activation) of NOX2 in immune cells
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.50 Pain Relevance 0.08
Mutations in the gp91phox gene (CYBB on chromosome Xp21.1) cause the X-linked recessive form of the disease that affects the majority of CGD patients (?
Positive_regulation (Mutations) of CYBB associated with disease and neutrophil disorders
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668749 Disease Relevance 1.00 Pain Relevance 0.18
Further, gp91phox and 3-nitrotyrosine in heart (7, 8), p22phox, Nox-4, and gp91phox in kidney (10), and p22phox in aorta (9) were increased in aldosterone/salt rats.
Positive_regulation (increased) of gp91phox in aorta
3) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.62 Pain Relevance 0.07
This was accompanied by an increase in O2*- production (60-240 min) in the RVLM, alongside phosphorylation of p47(phox) or p67(phox), upregulation of gp91(phox) or p47(phox) protein, and increase in Rac-1 or NADPH oxidase activity (60-120 min), and a depression of mitochondrial respiratory enzyme activity (120-240 min).
Positive_regulation (upregulation) of gp91 in respiratory associated with rostral ventrolateral medulla and depression
4) Confidence 0.01 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17448908 Disease Relevance 0.55 Pain Relevance 0.54

General Comments

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