INT143482

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 8.30
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
neuroblasts 4
radial 2
fat 2
gonadal 2
lymphocytes 2
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 144 99.72 Very High Very High Very High
antagonist 48 99.10 Very High Very High Very High
Inflammation 1 94.12 High High
metalloproteinase 64 94.08 High High
cytokine 1 88.08 High High
abdominal pain 1 79.60 Quite High
cINOD 2 50.28 Quite High
Chronic pancreatitis 3 50.00 Quite Low
alcohol 18 25.52 Quite Low
ischemia 32 22.24 Low Low
Disease Link Frequency Relevance Heat
Hypersensitivity 106 99.84 Very High Very High Very High
Adhesions 64 99.18 Very High Very High Very High
Apoptosis 1187 99.04 Very High Very High Very High
Targeted Disruption 16 98.56 Very High Very High Very High
Disorder Of Lipid Metabolism 58 98.20 Very High Very High Very High
Infection 1 97.08 Very High Very High Very High
INFLAMMATION 2 94.64 High High
Suicidal Behaviour 432 94.08 High High
Abdominal Pain 1 79.60 Quite High
Fatty Liver 60 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the TJ-10-treated rats, the rate of pancreatic acinar cell destruction, the apoptotic index at 12-20 weeks, and the expression of Fas and FasL at 12 and 20 weeks decreased significantly compared to those in untreated rats.
Negative_regulation (decreased) of Gene_expression (expression) of Fas in acinar cell
1) Confidence 0.41 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.06 Pain Relevance 0
Our observations suggest that celecoxib suppresses FAS expression and decreases fat accumulation by down-regulating JNK1.
Negative_regulation (suppresses) of Gene_expression (expression) of FAS in fat
2) Confidence 0.37 Published 2007 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17463161 Disease Relevance 0.15 Pain Relevance 0.05
As a result of the low SREBP-1c expression in rats fed SSC, there was a concomitant significant reduction in the expression of FAS, ME and G6PDH mRNA.
Negative_regulation (reduction) of Gene_expression (expression) of FAS associated with hypersensitivity
3) Confidence 0.34 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.60 Pain Relevance 0
Since estrogen induces neuroblasts to enter S-phase of cell cycle, while suppressing the cell-surface expression of Fas, we decided to examine the extent to which estrogen regulates cell cycle proteins concurrent with Fas activation.
Negative_regulation (suppressing) of Gene_expression (expression) of Fas in neuroblasts
4) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.26 Pain Relevance 0
Interestingly, the estrogen receptor antagonist, 4-hydroxytamoxifen, did not block estrogen suppression of Fas expression.
Negative_regulation (suppression) of Gene_expression (expression) of Fas associated with antagonist
5) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.30 Pain Relevance 0.05
Interestingly, in the context of our data on estrogen suppression of Fas expression, homozygous estrogen receptor-beta knockout animals exhibit defects in the organization of radial glia and increased apoptosis in cortical ventricular zone neuroblasts [63].
Negative_regulation (suppression) of Gene_expression (expression) of Fas in radial associated with targeted disruption and apoptosis
6) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0.05
Since Fas expression was also associated with p53 activation, we hypothesized that estrogen would suppress Fas expression in the context of p53 activation as well.
Negative_regulation (suppress) of Gene_expression (expression) of Fas
7) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.24 Pain Relevance 0.04
Thus, following p53 activation in our CHB50 cortical progenitors, we found that estrogen also led to a significant decrease in Fas expression.
Negative_regulation (decrease) of Gene_expression (expression) of Fas
8) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.32 Pain Relevance 0.05
These data are consistent with a recent report showing that integrin-mediated T-lymphocyte adhesion to extracellular matrix resulted in the suppression of Fas expression [62].
Negative_regulation (suppression) of Gene_expression (expression) of Fas in T-lymphocyte associated with adhesions
9) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.38 Pain Relevance 0.05
We therefore reasoned that estrogen suppresses apoptosis in the developing cerebral cortex, in part, by decreasing the cell-surface expression of the Fas receptor.
Negative_regulation (decreasing) of Gene_expression (expression) of Fas in cerebral cortex associated with apoptosis and cerebral cortex
10) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.68 Pain Relevance 0.11
The most parsimonious explanation for the data is that estrogen directly decreased Fas expression.
Negative_regulation (decreased) of Gene_expression (expression) of Fas
11) Confidence 0.34 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.38 Pain Relevance 0.04
FAS, ME and G6PDH mRNA expression was downregulated by SSC treatment, with a decrease of 20.1% (P < 0.05), 33.9% (P < 0.05) and 26.7% (P < 0.05) separately (Figure 3).


Negative_regulation (downregulated) of Gene_expression (expression) of FAS associated with hypersensitivity
12) Confidence 0.33 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.48 Pain Relevance 0
In the context of p53 activation, estrogen led to a significant decrease in the expression of Fas at 72 hours but not at 24 hours (Figure 8).
Negative_regulation (decrease) of Gene_expression (expression) of Fas
13) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.25 Pain Relevance 0.09
Consistent with the activity of the enzymes correlated to lipogenesis capacity, mRNA expression of FAS, G6PDH and ME decreased (35%,59% and 44%) (P < 0.01)dramatically by dietary cholesterol (Figure 1A).
Negative_regulation (decreased) of Gene_expression (expression) of FAS associated with disorder of lipid metabolism
14) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2820024 Disease Relevance 0.18 Pain Relevance 0
Activation of the transcription factor p53 was associated with induction of Fas expression, while the gonadal hormone estrogen antagonistically suppressed cell-surface Fas expression.
Negative_regulation (suppressed) of Gene_expression (expression) of Fas in gonadal
15) Confidence 0.25 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.60 Pain Relevance 0.03
It is likely therefore, that the induction of cyclin-A increases activation of associated kinases, even though CDK2 levels were not altered, leading to feedback activation of the estrogen receptor, further suppression of Fas expression, and neuro-protection.
Negative_regulation (suppression) of Gene_expression (expression) of Fas
16) Confidence 0.25 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.52 Pain Relevance 0
In contrast, the numbers of Fas expressing cells in cell cycle, S/G2/M, were not altered by estrogen exposure (Figure 7C), though estrogen led to a statistically significant 2-fold decrease in the intensity of cell-surface Fas expression (on a per-cell basis, Figure 7D).
Negative_regulation (numbers) of Gene_expression (expressing) of Fas
17) Confidence 0.25 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.21 Pain Relevance 0
One issue that remains to be addressed is whether estrogen suppresses cell-surface Fas expression by acting as a non-classical transcription repressor, or by suppressing translocation of Fas from intracellular compartments to the cell-surface in a manner that is antagonistic to that observed for p53 [34].
Spec (whether) Negative_regulation (suppresses) of Gene_expression (expression) of Fas
18) Confidence 0.25 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.04
Though estrogen did not alter the numbers of cells in cell cycle (S/G2/M) that expressed Fas, estrogen did lead to a significant decrease in the average intensity of Fas expression at the cell-surface.
Negative_regulation (decrease) of Gene_expression (expression) of Fas
19) Confidence 0.25 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.52 Pain Relevance 0.04
Functional determinants of Fas expression in cortical neuroblasts
Negative_regulation (determinants) of Gene_expression (expression) of Fas in neuroblasts
20) Confidence 0.25 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.59 Pain Relevance 0

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