INT143494

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 24.41
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DCPS) mitochondrion (DCPS) nucleolus (DCPS)
nucleus (DCPS) cytoplasm (DCPS)
Anatomy Link Frequency
DCs 4
spine 2
T cells 2
blood 1
plasma 1
DCPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 155 99.44 Very High Very High Very High
rheumatoid arthritis 179 99.24 Very High Very High Very High
Pain 53 98.44 Very High Very High Very High
backache 6 97.88 Very High Very High Very High
cytokine 112 97.72 Very High Very High Very High
headache 9 95.84 Very High Very High Very High
agonist 13 92.64 High High
chemokine 54 91.04 High High
behavioral therapy 68 89.44 High High
palliative 2 78.68 Quite High
Disease Link Frequency Relevance Heat
Cancer 535 100.00 Very High Very High Very High
Cold Sores 233 100.00 Very High Very High Very High
Malignant Neoplastic Disease 13 99.76 Very High Very High Very High
Adenocarcinoma 276 99.48 Very High Very High Very High
INFLAMMATION 159 99.44 Very High Very High Very High
Liver Cancer 1 99.34 Very High Very High Very High
Rheumatoid Arthritis 179 99.24 Very High Very High Very High
Prostate Cancer 92 99.00 Very High Very High Very High
Anxiety Disorder 37 98.68 Very High Very High Very High
Skin Cancer 119 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of HSV-1 to immature DCs depended on both DC-SIGN and heparan sulfate proteoglycans.
DCs Binding (Binding) of in DCs associated with cold sores
1) Confidence 0.29 Published 2008 Journal J. Gen. Virol. Section Abstract Doc Link 18796707 Disease Relevance 1.76 Pain Relevance 0.08
The newest CCE Standards should be seen as a call to action for all DCs and challenge not only the world's chiropractic teaching institutions, but every practicing chiropractic physician to rise to the occasion.
DCs Binding (call) of
2) Confidence 0.28 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1626475 Disease Relevance 0.53 Pain Relevance 0.08
The average case mix of DCs tends to include a significant amount of chronic spine patients although there is an indication that DCs utilize certain health promotion measures with them such as; exercise recommendations, ergonomic advice and advice on dietary changes [9].
DCs Binding (recommendations) of in spine
3) Confidence 0.28 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1626475 Disease Relevance 1.92 Pain Relevance 0.59
The average case mix of DCs tends to include a significant amount of chronic spine patients although there is an indication that DCs utilize certain health promotion measures with them such as; exercise recommendations, ergonomic advice and advice on dietary changes [9].
DCs Binding (recommendations) of in spine
4) Confidence 0.28 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1626475 Disease Relevance 1.76 Pain Relevance 0.51
DCs are involved in HSV-induced immune suppression, but little is known about the molecular interactions between DCs and HSV.
DCs Binding (interactions) of in DCs associated with cold sores
5) Confidence 0.27 Published 2008 Journal J. Gen. Virol. Section Abstract Doc Link 18796707 Disease Relevance 1.60 Pain Relevance 0.09
Our results suggest that tDCS applied to motor and non-motor areas according to the present tDCS safety guidelines, is associated with relatively minor adverse effects in healthy humans and patients with varying neurological disorders.
tDCS Binding (associated) of associated with neurological disease
6) Confidence 0.16 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17452283 Disease Relevance 1.08 Pain Relevance 0.37
Consequently, several clinical trials enrolling PCa patients were conducted, which were based on the administration of DCs pulsed with TAA-derived peptides, protein, or RNA.
DCs Binding (administration) of associated with prostate cancer
7) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.62 Pain Relevance 0
We hypothesized recruitment of pDCs into the inflamed RA synovial environment and their contribution as antigen-presenting cells (APCs) and inflammatory cells in RA.
pDCs Binding (recruitment) of associated with inflammation and rheumatoid arthritis
8) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065313 Disease Relevance 0.70 Pain Relevance 0.35
Together, the current and previous studies demonstrate recruitment of pDCs to normal lymphoid organs as well as inflammatory sites, with local differentiation, but no recruitment to normal peripheral tissues.
pDCs Neg (no) Binding (recruitment) of associated with inflammation
9) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.68 Pain Relevance 0.28
In tumor setting, DCs circulate through the blood and migrate to tumor tissues, where they interact with malignant cells.
DCs Binding (interact) of in blood associated with malignant neoplastic disease and cancer
10) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.27 Pain Relevance 0.19
Since only fully activated, mature DCs are able to migrate to lymph nodes and optimally promotes T cell activation, culturing mature DCs should strongly be encouraged for clinical trial use.
DCs Binding (encouraged) of in T cell
11) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.34 Pain Relevance 0.11
As fear reduction in exposure therapy is similar to extinction learning, DCS has been used recently in 2 investigations, one for the treatment of acrophobia, the other the treatment of social phobia, to determine whether DCS will also improve extinction of fear in human phobic patients undergoing behavioral exposure therapy.
DCS Binding (used) of associated with phobia and anxiety disorder
12) Confidence 0.07 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536545 Disease Relevance 0.91 Pain Relevance 0.18
DCs have been recognized as the main initiators of the adaptive immune response and play the pivotal role of tumor surveillance in healthy individuals.
DCs Binding (recognized) of associated with cancer
13) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2847547 Disease Relevance 1.06 Pain Relevance 0.04
This model was further developed to study the interaction between DCs and cancer (epithelial tumors and melanoma).
DCs Binding (interaction) of associated with cancer and skin cancer
14) Confidence 0.05 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.28 Pain Relevance 0.10
To this end, DCs express a number of pattern recognition receptors, which recognize specific molecular patterns exhibited on a variety of cell types and pathogens.
DCs Binding (recognize) of
15) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.88 Pain Relevance 0.03
In HLA-A*0201 patients, stimulator DCs were prepared from CD14+ cells purified from PBMC using CD14 MicroBeads and autoMACS separator (Miltenyi Biotec, Paris, France), cultured for 5 days in synthetic medium SYN-H (AbCys, Paris, France) containing 100 ng/ml rhGM-CSF and 20 ng/ml IL-4, and maturated with 10 ?
DCs Binding (maturated) of
16) Confidence 0.05 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.08 Pain Relevance 0
DCs generation, characterization and vaccine preparation
DCs Binding (generation) of
17) Confidence 0.05 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.20 Pain Relevance 0
Immature DCs decode and integrate such signals, and ferry this information to adaptive immune cells.
DCs Binding (integrate) of in immune cells
18) Confidence 0.04 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.75 Pain Relevance 0.11
On the one hand, if the direction of the DC flow is a key factor determining the (after-)effects of tDCS as suggested by recent modelling studies [7-13], then using an extracephalic reference electrode may potentially expand the variety of potential interventions with tDCS.
tDCS Binding (interventions) of
19) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0 Pain Relevance 0.03
Reduced CD83 expression by HSV-2-exposed DCs has been associated with lessened immunostimulatory function [16], [55], [56], but CD83 was not monitored in our study.
DCs Binding (associated) of associated with cold sores
20) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 1.09 Pain Relevance 0

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