INT143530

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 0.37
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Abcc1) transmembrane transport (Abcc1) cytoplasm (Abcc1)
oxidoreductase activity (Abcc1) nucleolus (Abcc1) nucleus (Abcc1)
Anatomy Link Frequency
trophoblast cells 4
erythrocytes 1
astrocytes 1
bile 1
placenta 1
Abcc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 69 99.64 Very High Very High Very High
Paracetamol 1 81.56 Quite High
Bioavailability 1 36.12 Quite Low
Angina 1 29.04 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 96.50 Very High Very High Very High
Gallstones 2 75.00 Quite High
Pressure And Volume Under Development 54 69.12 Quite High
Hepatocellular Cancer 4 54.20 Quite High
Stroke 1 29.48 Quite Low
Cv General 3 Under Development 1 29.04 Quite Low
Hypoxia 16 5.00 Very Low Very Low Very Low
Stress 16 5.00 Very Low Very Low Very Low
Toxicity 12 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the possibility of BPA-GA being transferred across the placenta by these transporters, we examined localization of Mrp1 and Oatp4a1 in the placenta by immunohistochemical analysis.
Spec (examined) Localization (localization) of Mrp1 in placenta
1) Confidence 0.74 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
In contrast, Mrp1, an efflux transporter, was localized on the basolateral membrane of the trophoblast cells (Figure 5G and arrows in Figure 5H).
Localization (localized) of Mrp1 in trophoblast cells
2) Confidence 0.74 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Our immunohistochemical analysis revealed that Oatp4a1 localizes on the apical membrane of trophoblast cells, and Mrp1 on the basolateral membrane.
Localization (localizes) of Mrp1 in trophoblast cells
3) Confidence 0.74 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Both Mrp1 and Oatp4a1 are known to transport endogenous estrogen conjugates, such as dehydroepiandrosterone-sulfate (DHEAS) and 17?
Localization (transport) of Mrp1
4) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
In the trophoblast cells, organic anion-transporting polypeptide 4a1 (Oatp4a1) was localized on the apical membrane, and multidrug resistance-associated protein 1 (Mrp1) was localized to the basolateral membrane.
Localization (localized) of Mrp1 in trophoblast cells
5) Confidence 0.65 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.03
In the trophoblast cells, organic anion-transporting polypeptide 4a1 (Oatp4a1) was localized on the apical membrane, and multidrug resistance-associated protein 1 (Mrp1) was localized to the basolateral membrane.
Localization (localized) of multidrug resistance-associated protein 1 in trophoblast cells
6) Confidence 0.65 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.03
Taken collectively, our findings indicate that TSB is a substrate for PgP and MRP1 and that drug resistance to TSB therapy and drug interactions may occur through PgP and MRP1 modulation.
Localization (modulation) of MRP1
7) Confidence 0.36 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0 Pain Relevance 0
In conclusion, SL administration to EE-induced cholestatic rats counteracted the decrease in bile flow and biliary excretion of glutathione and APAP-glu, a model Mrp substrate, findings associated with up-regulation of Mrp2 expression.
Localization (excretion) of Mrp in bile associated with bile
8) Confidence 0.29 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.07 Pain Relevance 0.18
Also, Darby et al. [74] recently suggested that MRP-mediated ATP release from rat astrocytes is present based on the observation that hypotonicity-induced ATP release was inhibited by an MRP inhibitor (MK571).
Localization (release) of MRP in astrocytes
9) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.14 Pain Relevance 0
Interestingly, CFTR knockout animals, in which MRP1 expression was found to be augmented, had an increased rate of ATP release from unstimulated erythrocytes, suggesting that ATP release was mediated by MRP1 but not by CFTR.
Neg (not) Localization (by) of MRP1 in erythrocytes associated with targeted disruption
10) Confidence 0.15 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.15 Pain Relevance 0

General Comments

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