INT143535

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Context Info
Confidence 0.86
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 3.43
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
skeletal muscle 1
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 99.88 Very High Very High Very High
cytokine 10 99.78 Very High Very High Very High
Inflammation 9 91.44 High High
Pain 1 80.56 Quite High
depression 1 80.08 Quite High
ketamine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
INFLAMMATION 15 99.70 Very High Very High Very High
Appetite Loss 7 99.28 Very High Very High Very High
Adult Respiratory Distress Syndrome 10 96.88 Very High Very High Very High
Pancreatic Cancer 1 96.48 Very High Very High Very High
Heart Rate Under Development 1 94.64 High High
Sepsis 23 89.28 High High
Lung Injury 2 88.88 High High
Heat Stress Disorders 21 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proposed mechanisms include the downregulation of the inflammatory response, and attenuation of TNF-?
Protein_catabolism (attenuation) of TNF associated with inflammatory response
1) Confidence 0.86 Published 2000 Journal Crit Care Section Body Doc Link PMC29035 Disease Relevance 1.51 Pain Relevance 0.13
The Ub-proteasome pathway seems to account for the majority of skeletal muscle degradation in cancer cachexia and is stimulated by several cytokines including tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, interferon-gamma and proteolysis-inducing factor.
Protein_catabolism (proteolysis-inducing) of tumor necrosis factor-alpha in skeletal muscle associated with appetite loss, necrosis, cancer and cytokine
2) Confidence 0.04 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17455154 Disease Relevance 1.92 Pain Relevance 0.20

General Comments

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