INT143536

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
skeletal muscle 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 7 98.82 Very High Very High Very High
corticosteroid 24 87.68 High High
Pain 1 80.56 Quite High
depression 1 80.08 Quite High
dexamethasone 5 56.60 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 99.32 Very High Very High Very High
Appetite Loss 7 99.28 Very High Very High Very High
Cancer 6 99.14 Very High Very High Very High
Pancreatic Cancer 1 96.48 Very High Very High Very High
Weight Loss 2 85.76 High High
Starvation 1 81.84 Quite High
Pain 1 80.56 Quite High
Depression 1 80.08 Quite High
Disease 2 75.68 Quite High
Frailty 3 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
where rate constants represent zero-order synthesis rate (ks_IL6R1m) and first-order degradation (kd_IL6R1m) of IL-6 receptor 1 mRNA.
Protein_catabolism (degradation) of IL-6
1) Confidence 0.69 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.11
The Ub-proteasome pathway seems to account for the majority of skeletal muscle degradation in cancer cachexia and is stimulated by several cytokines including tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, interferon-gamma and proteolysis-inducing factor.
Protein_catabolism (proteolysis-inducing) of interleukin-6 in skeletal muscle associated with appetite loss, necrosis, cancer and cytokine
2) Confidence 0.03 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17455154 Disease Relevance 1.89 Pain Relevance 0.20

General Comments

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