INT143551

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 13
Total Number 20
Disease Relevance 8.81
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
brain 3
SW480 1
KCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 679 100.00 Very High Very High Very High
local anesthetic 9 100.00 Very High Very High Very High
Endep 6 100.00 Very High Very High Very High
Neuronal excitability 2 94.08 High High
Neuropathic pain 17 86.28 High High
hyperexcitability 17 85.08 High High
antagonist 18 67.92 Quite High
Pain 33 60.16 Quite High
anesthesia 3 48.64 Quite Low
addiction 13 35.48 Quite Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 456 100.00 Very High Very High Very High
Cancer 194 99.16 Very High Very High Very High
Isaacs Syndrome 200 98.40 Very High Very High Very High
Colon Cancer 18 98.32 Very High Very High Very High
Syndrome 353 97.96 Very High Very High Very High
Toxicity 18 97.88 Very High Very High Very High
Death 54 97.16 Very High Very High Very High
Glioma 48 96.88 Very High Very High Very High
Neuromyelitis Optica 8 94.96 High High
Limbic Encephalitis 216 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By using a homolog series of local anesthetics with different lengths of the N-substituent, it was intended to elucidate the role of lipophilic interactions with Kv1.1.
Kv1 Binding (interactions) of associated with local anesthetic
1) Confidence 0.46 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18946303 Disease Relevance 0 Pain Relevance 0.31
Kv1.1 forms heteromeric channels with other subunits and interacts with other accessory subunits [16].
Kv1 Binding (interacts) of
2) Confidence 0.35 Published 2006 Journal Neurogenetics Section Body Doc Link PMC1820748 Disease Relevance 0.07 Pain Relevance 0.08
BACKGROUND: This study's aim was to investigate the interaction of amino-amide local anesthetics with human Kv1.1 potassium channels.
Kv1 Binding (interaction) of associated with potassium channel and local anesthetic
3) Confidence 0.30 Published 2008 Journal Anesthesiology Section Abstract Doc Link 18946303 Disease Relevance 0 Pain Relevance 0.32
Lipophilic and stereospecific interactions of amino-amide local anesthetics with human Kv1.1 channels.
Kv1 Binding (interactions) of associated with local anesthetic
4) Confidence 0.30 Published 2008 Journal Anesthesiology Section Title Doc Link 18946303 Disease Relevance 0 Pain Relevance 0.34
Mk1 and Mk2 were also implanted during 4 weeks with an osmotic pump, but delivering a control antibody.
Mk1 Binding (implanted) of
5) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1224856 Disease Relevance 0 Pain Relevance 0
Since the molecular mechanisms underlying these effects of amitriptyline have not been fully elucidated, we aimed to characterize the interaction of amitriptyline with human Kv1.1 and Kv7.2/7.3 channels.
Kv1.1 Binding (interaction) of associated with endep
6) Confidence 0.09 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17456683 Disease Relevance 0.26 Pain Relevance 0.41
We then tested the brain extract with commercial antibodies directed against proteins reported to associate with Kv1s: Lgi1, Caspr2 and contactin-2 (Poliak et al., 1999, 2003; Schulte et al., 2006).
Kv1s Binding (associate) of in brain
7) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.09
Most VGKC-antibodies bind to associated VGKC-complex proteins and not directly to Kv1 subunits
Kv1 Binding (directly) of associated with potassium channel
8) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 2.07 Pain Relevance 0.24
-DTX binds with high affinity to three different VGKC subunits, Kv1.1, 1.2 and 1.6.
Kv1 Binding (binds) of associated with potassium channel
9) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.14 Pain Relevance 0.18
From these results, we concluded that the majority of VGKC-antibody sera did not bind directly to Kv1 subunits but might bind to non-Kv1 proteins that remain complexed with the Kv1s in the rabbit brain digitonin extracts; digitonin is a mild detergent that does not dissociate all protein complexes.
Kv1 Neg (not) Spec (might) Binding (bind) of in brain associated with potassium channel
10) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.11
Five sera bound to contactin-2 itself but four of these sera also bound to Kv1, Caspr2 or Lgi1.


Kv1 Binding (bound) of
11) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.39 Pain Relevance 0.14
-DTX-labelled Kv1 complexes, showing that 93/96 of the patientsÂ’ antibodies did not bind the Kv1s at detectable levels.
Kv1s Neg (not) Binding (bind) of
12) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.18
Figure 1VGKC-antibodies immunoprecipitate VGKCs from brain extracts but do not bind directly to Kv1 subunits.
Kv1 Neg (not) Binding (bind) of in brain
13) Confidence 0.07 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.33 Pain Relevance 0.26
Surprisingly, only a few patients had antibodies binding to the Kv1 subunits themselves but most bound only to one of two proteins, leucine-rich glioma inactivated 1 (Lgi1) or contactin-associated protein-2 (Caspr2), that are part of the ?
Kv1 Binding (binding) of associated with glioma
14) Confidence 0.07 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.50 Pain Relevance 0.15
As expected, EA could interact with multiple proteins in CLL extracts, but did not bind detectably to ?
EA Binding (interact) of associated with chronic lymphoid leukemia
15) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.46 Pain Relevance 0
To test whether EA could similarly interact with LEF-1 in other tumor cells, a human colon cancer cell line SW480 was tested.
EA Binding (interact) of in SW480 associated with cancer and colon cancer
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.53 Pain Relevance 0
In contrast, neither BHA, which scavenges reactive oxygen species (ROS), but does not have a free thiol, nor PDTC, which does react efficiently with EA, did not reverse the Wnt inhibition (Figure 6A).
EA Neg (neither) Binding (react) of
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.62 Pain Relevance 0
Because EA can bind to any free thiol, it is likely that the mechanism of EA-induced cell death is variable and will depend upon cell type and context.
EA Binding (bind) of associated with death
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 1.50 Pain Relevance 0
Subsequent studies showed that EA could not bind to ?
EA Neg (not) Binding (bind) of
19) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.40 Pain Relevance 0.03
As expected, EA could interact with multiple proteins in CLL extracts, but did not bind detectably to ?
EA Neg (not) Binding (bind) of associated with chronic lymphoid leukemia
20) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.52 Pain Relevance 0

General Comments

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