INT143557

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.34
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
central nervous system 1
Ido1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 15 100.00 Very High Very High Very High
Central nervous system 6 99.96 Very High Very High Very High
depression 35 99.40 Very High Very High Very High
Inflammation 10 99.22 Very High Very High Very High
cytokine 20 99.10 Very High Very High Very High
Analgesic 17 97.88 Very High Very High Very High
nMDA receptor 10 97.76 Very High Very High Very High
agonist 10 96.56 Very High Very High Very High
withdrawal 28 94.16 High High
Neurotransmitter 5 80.60 Quite High
Disease Link Frequency Relevance Heat
Overdose 68 100.00 Very High Very High Very High
Depression 40 99.76 Very High Very High Very High
Necrosis 5 99.72 Very High Very High Very High
Cancer 5 99.54 Very High Very High Very High
INFLAMMATION 15 99.22 Very High Very High Very High
Suicidal Behaviour 14 87.48 High High
Emergencies 4 79.08 Quite High
Self Harm 2 66.92 Quite High
Poisoning 3 66.40 Quite High
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The smaller increase in IDO presentations involving other prescription compound analgesics constituted evidence of some substitution.
Positive_regulation (increase) of IDO associated with analgesic and overdose
1) Confidence 0.40 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2858125 Disease Relevance 0.96 Pain Relevance 0.43
An increased activation of IDO and its subsequent enzyme kynurenine monooxygenase by proinflammatory cytokines, moreover, leads to an enhanced production of quinolinic acid, a strong agonist of the glutamatergic N-methyl-D-aspartate receptor.
Positive_regulation (activation) of IDO associated with nmda receptor, agonist and cytokine
2) Confidence 0.36 Published 2007 Journal Mol. Psychiatry Section Abstract Doc Link 17457312 Disease Relevance 0.91 Pain Relevance 0.93
Depressive states during inflammatory somatic disorders are also associated with increased proinflammatory cytokines and increased consumption of tryptophan via activation of IDO.
Positive_regulation (activation) of IDO associated with depression, inflammation and cytokine
3) Confidence 0.36 Published 2007 Journal Mol. Psychiatry Section Abstract Doc Link 17457312 Disease Relevance 0.90 Pain Relevance 0.88
Proinflammatory cytokines such as interleukin-2, interferon-gamma, or tumor necrosis factor-alpha activate the tryptophan- and serotonin-degrading enzyme indoleamine 2,3-dioxygenase (IDO).
Positive_regulation (activate) of IDO associated with necrosis, cancer, serotonin and cytokine
4) Confidence 0.29 Published 2007 Journal Mol. Psychiatry Section Abstract Doc Link 17457312 Disease Relevance 0.93 Pain Relevance 0.79
An enhanced consumption of serotonin and its precursor tryptophan through IDO activation could well explain the reduced availability of serotonergic neurotransmission in MD.
Positive_regulation (activation) of IDO associated with depression and serotonin
5) Confidence 0.24 Published 2007 Journal Mol. Psychiatry Section Abstract Doc Link 17457312 Disease Relevance 0.88 Pain Relevance 0.89
In inflammatory states of the central nervous system, IDO is mainly activated in microglial cells, which preferentially metabolize tryptophan to the NMDA receptor agonist quinolinic acid, whereas astrocytes - counteracting this metabolism due to the lack of an enzyme of this metabolism - have been observed to be reduced in MD.
Positive_regulation (activated) of IDO in central nervous system associated with depression, inflammation, nmda receptor, agonist and central nervous system
6) Confidence 0.24 Published 2007 Journal Mol. Psychiatry Section Abstract Doc Link 17457312 Disease Relevance 0.77 Pain Relevance 0.88

General Comments

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