INT14357

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 7.14
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FCGR1A) plasma membrane (FCGR1A)
Anatomy Link Frequency
synovium 3
nodules 3
spinal cord 1
heart 1
melanotrophs 1
FCGR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 26 100.00 Very High Very High Very High
Spinal cord 2 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
cva 3 98.86 Very High Very High Very High
Acupuncture 125 98.64 Very High Very High Very High
rheumatoid arthritis 18 98.48 Very High Very High Very High
analgesia 8 98.16 Very High Very High Very High
Pain 26 96.68 Very High Very High Very High
opioid receptor 4 95.40 Very High Very High Very High
Intracerebroventricular 5 94.92 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 5 99.76 Very High Very High Very High
Bordatella Infection 2 99.12 Very High Very High Very High
Cv General 3 Under Development 3 98.86 Very High Very High Very High
Rheumatoid Arthritis 18 98.48 Very High Very High Very High
Hypothermia 9 98.04 Very High Very High Very High
Hypersensitivity 6 97.52 Very High Very High Very High
Pain 29 96.68 Very High Very High Very High
Osteoarthritis 18 94.68 High High
Low Back Pain 6 93.76 High High
Sarcoidosis 6 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, bamiphylline had little effect on anginal pain, suggesting that this cannot be mediated exclusively by A1-receptor stimulation in these patients.
Positive_regulation (stimulation) of A1-receptor associated with cva
1) Confidence 0.44 Published 1997 Journal G Ital Cardiol Section Abstract Doc Link 9199943 Disease Relevance 0.72 Pain Relevance 0.33
Nerve injury results in increased tonic spinal cord adenosine A1 receptor activation, consistent with a role for adenosine to generate hypersensitivity.
Positive_regulation (increased) of A1 receptor in spinal cord associated with adenocard, nervous system injury, hypersensitivity and spinal cord
2) Confidence 0.41 Published 2006 Journal Neuroreport Section Abstract Doc Link 17001280 Disease Relevance 0.86 Pain Relevance 0.60
Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster.
Positive_regulation (activation) of A1-receptor in heart associated with adenocard
3) Confidence 0.41 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 18596109 Disease Relevance 0.56 Pain Relevance 0.18
We have investigated the distribution of cells bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in 14 synovia and 3 nodules from rheumatoid arthritis (RA) patients, using monoclonal antibodies on serial cryostat sections. 8 osteoarthritis (OA), 2 ankylosing spondylitis (AS) patients and one sarcoid patient were also studied.
Spec (investigated) Positive_regulation (bearing) of Fc gamma R in nodules associated with spinal inflammation, sarcoidosis, rheumatoid arthritis and osteoarthritis
4) Confidence 0.14 Published 1990 Journal Scand. J. Rheumatol. Section Abstract Doc Link 1692420 Disease Relevance 0.70 Pain Relevance 0.35
The prevalence and distribution of macrophages bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in synovium.
Positive_regulation (bearing) of Fc gamma R in synovium
5) Confidence 0.14 Published 1990 Journal Scand. J. Rheumatol. Section Title Doc Link 1692420 Disease Relevance 0.67 Pain Relevance 0.34
We have investigated the distribution of cells bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in 14 synovia and 3 nodules from rheumatoid arthritis (RA) patients, using monoclonal antibodies on serial cryostat sections. 8 osteoarthritis (OA), 2 ankylosing spondylitis (AS) patients and one sarcoid patient were also studied.
Spec (investigated) Positive_regulation (bearing) of Fc gamma R in nodules associated with spinal inflammation, sarcoidosis, rheumatoid arthritis and osteoarthritis
6) Confidence 0.14 Published 1990 Journal Scand. J. Rheumatol. Section Abstract Doc Link 1692420 Disease Relevance 0.71 Pain Relevance 0.35
We have investigated the distribution of cells bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in 14 synovia and 3 nodules from rheumatoid arthritis (RA) patients, using monoclonal antibodies on serial cryostat sections. 8 osteoarthritis (OA), 2 ankylosing spondylitis (AS) patients and one sarcoid patient were also studied.
Spec (investigated) Positive_regulation (bearing) of Fc gamma R I in nodules associated with spinal inflammation, sarcoidosis, rheumatoid arthritis and osteoarthritis
7) Confidence 0.14 Published 1990 Journal Scand. J. Rheumatol. Section Abstract Doc Link 1692420 Disease Relevance 0.69 Pain Relevance 0.35
The prevalence and distribution of macrophages bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in synovium.
Positive_regulation (bearing) of Fc gamma R in synovium
8) Confidence 0.14 Published 1990 Journal Scand. J. Rheumatol. Section Title Doc Link 1692420 Disease Relevance 0.67 Pain Relevance 0.33
The prevalence and distribution of macrophages bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in synovium.
Positive_regulation (bearing) of Fc gamma R I in synovium
9) Confidence 0.14 Published 1990 Journal Scand. J. Rheumatol. Section Title Doc Link 1692420 Disease Relevance 0.66 Pain Relevance 0.33
and IL6 responses appeared to be similar in the knockouts as judged by a comparable induction of the known feedback regulators of the major cytokine and growth factor signaling pathways such as SOCS3, IGFR1, DUSP1 and DUSP 6.
Positive_regulation (induction) of IGFR1 associated with cytokine
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.05
Moreover, a very recent study has found that the underlying analgesia efficacy of acupuncture mainly involves the underlying molecular pathways, particularly by activating A1 receptor [12].
Positive_regulation (activating) of A1 receptor associated with acupuncture and analgesia
11) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989943 Disease Relevance 0.53 Pain Relevance 1.09
The present study demonstrates that in frog melanotrophs adenosine inhibits the electrical activity by activating IK through an A1 receptor subtype coupled to a pertussis toxin-sensitive pathway independent of the cAMP/PKA system.
Positive_regulation (activating) of A1 receptor in melanotrophs associated with adenocard and bordatella infection
12) Confidence 0.02 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630670 Disease Relevance 0.18 Pain Relevance 0.28
These results suggest that activation of the A1-receptor by adenosine is important for the generation of hypothermia in the entrance phase, and that activation of the mu1-opioid receptor by opioid peptides is required for perpetuation of hypothermia in the maintenance phase.
Positive_regulation (activation) of A1-receptor associated with hypothermia, adenocard, opioid receptor and opioid
13) Confidence 0.01 Published 2005 Journal Brain Res. Section Abstract Doc Link 15910766 Disease Relevance 0.19 Pain Relevance 0.82

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