INT14360

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.97
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DDC) small molecule metabolic process (DDC) lyase activity (DDC)
cellular nitrogen compound metabolic process (DDC) cellular amino acid metabolic process (DDC) cytoplasm (DDC)
Anatomy Link Frequency
neurons 2
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 68 99.80 Very High Very High Very High
Dopamine 241 99.46 Very High Very High Very High
monoamine 8 97.96 Very High Very High Very High
Raphe 8 92.56 High High
midbrain 41 91.24 High High
Substantia nigra 8 88.96 High High
GCH1 4 73.20 Quite High
Bioavailability 1 72.80 Quite High
gABA 10 70.44 Quite High
medulla 1 55.16 Quite High
Disease Link Frequency Relevance Heat
Disease 125 99.20 Very High Very High Very High
Infection 3 98.52 Very High Very High Very High
Parkinson's Disease 23 95.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 95.40 Very High Very High Very High
Diplopia 1 94.00 High High
Lymphatic System Cancer 2 85.48 High High
Metastasis 19 82.08 Quite High
Toxicity 8 81.36 Quite High
Secondary Parkinson Disease 8 79.52 Quite High
Syndrome 5 77.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like the other dideoxynucleosides, activation of ddC is dependent on intracellular phosphorylation to its 5'-triphosphate form.
Positive_regulation (activation) of ddC
1) Confidence 0.70 Published 1990 Journal Am. J. Med. Section Abstract Doc Link 1692446 Disease Relevance 0.92 Pain Relevance 0.11
LIM homeobox transcription factor 1b (Lmx1b), and the enzymes of the dopamine synthetic pathway, TH and aromatic L-amino acid decarboxylase (AADC), were detected at substantially higher levels in cultures influenced by SPIE, as compared to randomly-differentiated cultures.
Positive_regulation (aromatic) of AADC associated with dopamine
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.19
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Positive_regulation (required) of Aadc in neurons associated with serotonin and monoamine
3) Confidence 0.49 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.06 Pain Relevance 0.38
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Positive_regulation (required) of dopa decarboxylase in neurons associated with serotonin and monoamine
4) Confidence 0.49 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.38
However, this apparently more simple approach could be more risky as there is no inherent feedback mechanism in the control of AADC activity and increased concentrations of AADC could lead to dopamine over production.
Positive_regulation (increased) of AADC associated with dopamine
5) Confidence 0.29 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.05 Pain Relevance 0.41
Sprouting of remaining dopaminergic fibres after neurotoxic challenge has been reported in 6-OHDA lesion models of PD, and changes in presynaptic terminals, upregulation of AADC levels to increase dopamine conversions and reduced dopamine transporter have been demonstrated both in MPTP primate models and PD patients.
Positive_regulation (upregulation) of AADC associated with parkinson's disease, dopamine and disease
6) Confidence 0.27 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.37 Pain Relevance 0.20
LIM homeobox transcription factor 1b (Lmx1b), and the enzymes of the dopamine synthetic pathway, TH and aromatic L-amino acid decarboxylase (AADC), were detected at substantially higher levels in cultures influenced by SPIE, as compared to randomly-differentiated cultures.
Positive_regulation (aromatic) of L-amino acid decarboxylase associated with dopamine
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.19
Many of the patients described in these studies have been reported to be responsive to L-DOPA [8].
Positive_regulation (responsive) of L-DOPA
8) Confidence 0.07 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2914667 Disease Relevance 1.49 Pain Relevance 0.16

General Comments

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