INT143601

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.44
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2)
DNA binding (Erbb2) cytoplasm (Erbb2)
Anatomy Link Frequency
spinal cord 1
Erbb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 3 100.00 Very High Very High Very High
Pain 4 83.56 Quite High
cytokine 2 75.00 Quite High
intrathecal 1 63.28 Quite High
withdrawal 1 54.88 Quite High
central sensitization 1 28.32 Quite Low
Lasting pain 1 25.00 Low Low
nociceptor 1 25.00 Low Low
medulla 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pheochromocytoma 51 99.80 Very High Very High Very High
Malignant Neoplastic Disease 35 97.36 Very High Very High Very High
Cancer 23 96.08 Very High Very High Very High
Leukemia 2 75.68 Quite High
Pain 2 75.00 Quite High
Paraganglioma 14 67.24 Quite High
Nociception 1 34.32 Quite Low
Benign Tumor 6 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Breast Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that there may be certain progression of genetic events that involves chromosomes 1p, 3p, 6p, 11q, 12q, 17q, and 19q in the development of pheochromocytomas, and the activation of ERBB-2 located on chromosome 17q is an important and early event in the malignancy development of these tumor types.
Positive_regulation (activation) of ERBB-2 associated with malignant neoplastic disease, cancer and pheochromocytoma
1) Confidence 0.46 Published 2008 Journal Endocrine-Related Cancer Section Abstract Doc Link PMC2254511 Disease Relevance 1.36 Pain Relevance 0
We observed that expression of NRG1 mRNA and the neuregulin receptors, ErbB2 and ErbB4 in the lumbar spinal cord was facilitated by the presence of progesterone in female rats following L5 nerve root ligation.
Positive_regulation (facilitated) of ErbB2 in spinal cord associated with spinal cord
2) Confidence 0.17 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17459743 Disease Relevance 0.07 Pain Relevance 0.39

General Comments

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