INT143623

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 3.18
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dpysl2) cytosol (Dpysl2) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (Dpysl2)
mitochondrion (Dpysl2) protein complex (Dpysl2) cytoplasm (Dpysl2)
Anatomy Link Frequency
neuronal 4
Dpysl2 (Mus musculus)
Pain Link Frequency Relevance Heat
lacosamide 513 100.00 Very High Very High Very High
Neuronal excitability 5 99.38 Very High Very High Very High
sodium channel 25 96.60 Very High Very High Very High
Analgesic 5 90.24 High High
anticonvulsant 8 89.68 High High
dorsal root ganglion 111 86.96 High High
IPN 2 86.12 High High
Antinociceptive 2 80.80 Quite High
antiepileptic Drug 58 75.20 Quite High
headache 15 48.48 Quite Low
Disease Link Frequency Relevance Heat
Disease 8 99.00 Very High Very High Very High
Adhesions 3 87.60 High High
Epilepsy 67 87.04 High High
Ganglion Cysts 114 86.96 High High
Shock 66 86.32 High High
Inflammatory Pain 2 86.12 High High
Neuropathic Pain 9 84.64 Quite High
Convulsion 206 79.72 Quite High
Partial Seizures 31 75.00 Quite High
Toxicity 2 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRMP-2 is involved in neuronal differentiation and network building and control of axonal outgrowth and probably also epileptogenesis. 13 Further research is needed to determine whether the interaction between lacosamide and CRMP2 leads to symptomatic or disease-modifying effects.14
CRMP2 Spec (whether) Binding (interaction) of in neuronal associated with lacosamide and disease
1) Confidence 0.48 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938295 Disease Relevance 0.56 Pain Relevance 0.40
In addition, LCM seems to interact with
                   collapsin-response mediator protein 2 and thus may mediate neuronal plasticity.
                   
mediator protein 2 Binding (interact) of in neuronal associated with lacosamide
2) Confidence 0.40 Published 2009 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2754090 Disease Relevance 0.13 Pain Relevance 0.45
It selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing without exhibiting effects on physiological neuronal excitability (Figure 1).12 Lacosamide also binds to collapsing-response mediator protein-2 (CRMP2), a phosphoprotein that is expressed mainly in the nervous system.
CRMP2 Binding (binds) of in neuronal associated with neuronal excitability, sodium channel and lacosamide
3) Confidence 0.36 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938295 Disease Relevance 0.34 Pain Relevance 0.48
It also binds to a collapsing-response mediator protein-2, CRMP2.
mediator protein-2 Binding (binds) of
4) Confidence 0.31 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2938295 Disease Relevance 0.27 Pain Relevance 0.28
It also binds to a collapsing-response mediator protein-2, CRMP2.
CRMP2 Binding (binds) of
5) Confidence 0.31 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2938295 Disease Relevance 0.28 Pain Relevance 0.28
It selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing without exhibiting effects on physiological neuronal excitability (Figure 1).12 Lacosamide also binds to collapsing-response mediator protein-2 (CRMP2), a phosphoprotein that is expressed mainly in the nervous system.
mediator protein-2 Binding (binds) of in neuronal associated with neuronal excitability, sodium channel and lacosamide
6) Confidence 0.31 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938295 Disease Relevance 0.34 Pain Relevance 0.48
CRMP2 binds to ??
CRMP2 Binding (binds) of
7) Confidence 0.21 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.45 Pain Relevance 0.11
Although we were unable to detect physical interactions between PlexinA1 nor CRMP2 with either kinase, we observed that both PlexinA1 and CRMP2 inhibited the autophosphorylation activities of Fps and Fer.
CRMP2 Binding (interactions) of
8) Confidence 0.16 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0 Pain Relevance 0
To test for associations between CRMP2 and Fps and Fer, this experiment was also performed using the anti-Fps/Fer antibody to isolate the Fps and Fer proteins, followed by immunoblotting with anti-Myc to assess the presence of associated CRMP2 protein.
CRMP2 Binding (associations) of
9) Confidence 0.16 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.21 Pain Relevance 0.07
Furthermore, employing proteomic affinity-labeling techniques, collapsin-response mediator protein 2 (CRMP-2 alias DRP-2) was identified as a binding partner.
CRMP-2 Binding (binding) of
10) Confidence 0.14 Published 2007 Journal CNS Drug Rev Section Abstract Doc Link 17461888 Disease Relevance 0.31 Pain Relevance 0.70
Follow-up experiments confirmed a functional interaction of LCM with CRMP-2 in vitro.
CRMP-2 Binding (interaction) of associated with lacosamide
11) Confidence 0.12 Published 2007 Journal CNS Drug Rev Section Abstract Doc Link 17461888 Disease Relevance 0.30 Pain Relevance 0.69

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