INT143643

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Fasn) lyase activity (Fasn) oxidoreductase activity (Fasn)
Golgi apparatus (Fasn) plasma membrane (Fasn) cytoplasm (Fasn)
Anatomy Link Frequency
nucleus 2
Fasn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 2 97.96 Very High Very High Very High
cytokine 3 6.68 Low Low
tolerance 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 5 99.46 Very High Very High Very High
INFLAMMATION 3 97.24 Very High Very High Very High
Body Weight 4 87.80 High High
Metabolic Syndrome 10 87.20 High High
Weight Gain 1 86.04 High High
Obesity 4 74.32 Quite High
Diabetes Mellitus 21 61.00 Quite High
Overweight 1 43.12 Quite Low
Cancer 7 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1.
Negative_regulation (decreases) of Gene_expression (expression) of fatty acid synthase
1) Confidence 0.23 Published 2007 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 17463161 Disease Relevance 0.24 Pain Relevance 0.19
In addition, the inhibition of growth and suppression of lipogenesis in MCF-7 breast cancer cells may be through down-regulation of fatty acid synthase gene expression in the nucleus and stimulation of cell energy expenditure in the mitochondria [107,108].
Negative_regulation (regulation) of Gene_expression (expression) of fatty acid synthase gene in nucleus associated with breast cancer
2) Confidence 0.02 Published 2010 Journal Chin Med Section Body Doc Link PMC2855614 Disease Relevance 0.72 Pain Relevance 0

General Comments

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