INT143646

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 5.46
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8ip1) signal transduction (Mapk8ip1) mitochondrion (Mapk8ip1)
vesicle-mediated transport (Mapk8ip1) endoplasmic reticulum (Mapk8ip1) nucleus (Mapk8ip1)
Anatomy Link Frequency
fat 1
frontal cortex 1
Mapk8ip1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 6 99.24 Very High Very High Very High
fluoxetine 4 99.12 Very High Very High Very High
ischemia 84 88.80 High High
depression 8 88.48 High High
antidepressant 4 82.16 Quite High
cINOD 4 56.84 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 99.90 Very High Very High Very High
Apoptosis 180 99.38 Very High Very High Very High
Urological Neuroanatomy 6 98.08 Very High Very High Very High
Myocardial Reperfusion Injury 48 93.40 High High
Death 16 93.04 High High
Injury 60 90.16 High High
Cv Unclassified Under Development 40 88.80 High High
Coronary Artery Disease 44 88.56 High High
Depression 8 88.48 High High
Obesity 4 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the potential molecular targets by which celecoxib may regulate FAS expression, only c-Jun N-terminal kinase-1 (JNK1) was significantly down-regulated.
Negative_regulation (down-regulated) of JNK1
1) Confidence 0.03 Published 2007 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17463161 Disease Relevance 0.22 Pain Relevance 0.11
Our observations suggest that celecoxib suppresses FAS expression and decreases fat accumulation by down-regulating JNK1.
Negative_regulation (down-regulating) of JNK1 in fat
2) Confidence 0.03 Published 2007 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17463161 Disease Relevance 0.14 Pain Relevance 0
Western blot study revealed that rats subjected to prenatal stress had decreased levels of p-JNK1 and p-JNK2 in the hippocampus and p-p38 in the frontal cortex, but the concentrations of p-ERK1 and p-ERK2 were not changed.
Negative_regulation (decreased) of p-JNK1 in frontal cortex associated with stress, urological neuroanatomy and hippocampus
3) Confidence 0.01 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436222 Disease Relevance 1.02 Pain Relevance 0.47
Chronic treatment with imipramine inhibited the stress-induced decrease in p-JNK1/2, while imipramine, fluoxetine and mirtazapine blocked changes in p-p38.
Negative_regulation (decrease) of p-JNK1 associated with stress and fluoxetine
4) Confidence 0.01 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436222 Disease Relevance 0.85 Pain Relevance 0.42
This anti-apoptotic effect of ALA was observed to be closely associated with the inhibition of ROS generation, the increased activity of pERK 1/2 and the decreased activity of pJNK 1/2.
Negative_regulation (decreased) of pJNK 1 associated with apoptosis
5) Confidence 0.01 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.48 Pain Relevance 0.18
The ROS generation was significantly suppressed (p<0.0001), the activity of pERK 1/2 was significantly increased (p<0.05) and the activity of pJNK 1/2 was significantly decreased (p<0.05) in the ALA 25 mg/kg group compared to the controls.


Negative_regulation (decreased) of pJNK 1
6) Confidence 0.01 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2771824 Disease Relevance 0.32 Pain Relevance 0
These findings suggest that the cardioprotective effects of ALA treatment prior to reperfusion were closely associated with the suppression of apoptosis due to increased pERK 1/2 and decreased pJNK 1/2.
Negative_regulation (decreased) of pJNK 1 associated with apoptosis
7) Confidence 0.01 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.10 Pain Relevance 0.10
This cardioprotective activity of ALA might be associated with an anti-apoptotic effect of ALA via suppression of ROS generation, increase of pERK 1/2 and decrease of pJNK 1/2 activity.



Negative_regulation (decrease) of pJNK 1 associated with apoptosis
8) Confidence 0.01 Published 2009 Journal Korean Circulation Journal Section Abstract Doc Link PMC2771824 Disease Relevance 0.34 Pain Relevance 0

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