INT143663

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.32
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
trigeminal ganglion 2
neurons 2
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 68 100.00 Very High Very High Very High
Acute pain 2 99.96 Very High Very High Very High
Neuropathic pain 18 99.68 Very High Very High Very High
Pain 53 97.68 Very High Very High Very High
Antinociceptive 18 96.76 Very High Very High Very High
Spinal cord 12 94.44 High High
Dorsal horn 6 93.68 High High
dorsal root ganglion 1 92.60 High High
antinociception 6 92.00 High High
gABA 79 91.96 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 93 100.00 Very High Very High Very High
Targeted Disruption 2 100.00 Very High Very High Very High
Pain 53 99.96 Very High Very High Very High
Neuropathic Pain 22 99.68 Very High Very High Very High
Generalized Anxiety Disorder 30 93.28 High High
Nervous System Injury 6 48.56 Quite Low
Injury 6 29.52 Quite Low
Cold Sores 4 14.32 Low Low
Nociception 14 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both allodynic and hyperalgeic behavior tests suggested that neuropathic pain was noticeably reduced, along with the transgenic GAD65 expression.
Negative_regulation (reduced) of Gene_expression (expression) of GAD65 associated with targeted disruption and neuropathic pain
1) Confidence 0.43 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.81 Pain Relevance 0.85
The present study shows that adenoviral transfer of the GAD65 gene into satellite glial cells (SGCs) of the trigeminal ganglion is sufficient to reduce acute pain behavior resulting from the orofacial formalin test.
Negative_regulation (reduce) of Gene_expression (transfer) of GAD65 in trigeminal ganglion associated with ganglion cysts, acute pain and trigeminal ganglion
2) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.87 Pain Relevance 0.95
The principal evidence is that GAD65 expression was present principally in SGCs and only occasionally in neurons.
Negative_regulation (present) of Gene_expression (expression) of GAD65 in neurons
3) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.65 Pain Relevance 0.96

General Comments

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