INT143664

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.03
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myocardium 1
PSCs 1
ST2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 110 100.00 Very High Very High Very High
Inflammation 316 95.20 Very High Very High Very High
tolerance 3 92.12 High High
cytokine 279 90.48 High High
Sciatic nerve 1 82.76 Quite High
fibrosis 8 67.36 Quite High
Chronic pancreatitis 1 62.52 Quite High
Angina 22 50.00 Quite Low
nud 1 30.04 Quite Low
headache 5 29.60 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 27 98.36 Very High Very High Very High
Asthma 951 95.56 Very High Very High Very High
Myocardial Infarction 32 95.48 Very High Very High Very High
INFLAMMATION 343 95.20 Very High Very High Very High
Stress 12 92.48 High High
Atherosclerotic Plaque 10 91.84 High High
Coagulation Disorder 1 91.48 High High
Soft Tissue Injuries 2 86.44 High High
Targeted Disruption 60 85.84 High High
Eosinophilia 57 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a post hoc analysis, patients with outlying increased ST2 values were examined to determine possible alternative causes for ST2 expression.
Spec (determine) Gene_expression (expression) of ST2
1) Confidence 0.77 Published 2007 Journal Ann Emerg Med Section Body Doc Link 17466411 Disease Relevance 0 Pain Relevance 0
It is known that ST2 directs Th2 lymphocyte function; this finding suggests that ST2 is induced in conditions of myocardial overload such as myocardial infarction, when the remaining viable myocardium must bear more stress.
Gene_expression (directs) of ST2 in myocardium associated with stress and myocardial infarction
2) Confidence 0.54 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.18 Pain Relevance 0.14
The protein product of ST2 encodes a transmembrane receptor form (ST2L) and a truncated soluble receptor form (ST2) that can be detected in human serum.
Gene_expression (detected) of ST2
3) Confidence 0.42 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.12 Pain Relevance 0.15
PSCs expressed soluble ST2, ST2L, and IL-1RAcP, but the expression level of ST2L was relatively low.
Gene_expression (expressed) of ST2 in PSCs
4) Confidence 0.28 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20689058 Disease Relevance 0.33 Pain Relevance 0.13
However, if signalling via ST2L is in fact only important during the induction of a Th2 response, then production of soluble ST2 in response to antigenic challenge when allergic sensitization has already been established seems unlikely to achieve much in terms of autoregulation.
Gene_expression (production) of ST2 associated with hypersensitivity
5) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.73 Pain Relevance 0.09
Three distinct types of ST2 (also known as T1, Fit-1, and DER4) gene products have been cloned; a soluble secreted form (ST2), a transmembrane receptor form (ST2L), and a variant form (ST2V).
Gene_expression (products) of ST2
6) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.50 Pain Relevance 0.16
Anti-T1/ST2 also induces the selective expression of IL-4 but not IFN-?
Gene_expression (/) of ST2
7) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.14 Pain Relevance 0.12
During his OR course the patient's StO2 dropped to 51% just prior to transfer to the ICU.
Gene_expression (transfer) of StO2
8) Confidence 0.10 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.70 Pain Relevance 0.04
For the active acupuncture group, 10 acupuncture points (bilateral LI4, LI20, ST2, and ST36, unilateral EX-1 and GV23) according to 'WHO Standard Acupuncture Point Location' [18] were selected for use based on an expert discussion held in Beijing in December, 2008.
Gene_expression (selected) of ST2 associated with acupuncture
9) Confidence 0.10 Published 2009 Journal Trials Section Body Doc Link PMC2715403 Disease Relevance 0.07 Pain Relevance 0.90
In the moderate endemic areas, there was no difference between the ST2 and ST1 groups (p>0.05).
Gene_expression (groups) of ST2
10) Confidence 0.07 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.14 Pain Relevance 0
0.1–0.3 for ST2-mod; RR?
Gene_expression (0.3) of ST2
11) Confidence 0.07 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.13 Pain Relevance 0

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