INT143666

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.76
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myocardium 1
tibia 1
abdomen 1
chest 1
Th2 cells 1
ST2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 31 99.76 Very High Very High Very High
ischemia 13 98.32 Very High Very High Very High
Inflammation 220 96.96 Very High Very High Very High
cytokine 189 96.16 Very High Very High Very High
tolerance 2 55.60 Quite High
Inflammatory marker 2 40.00 Quite Low
Sciatic nerve 7 8.32 Low Low
antagonist 68 5.00 Very Low Very Low Very Low
chemokine 46 5.00 Very Low Very Low Very Low
agonist 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Angina 10 99.76 Very High Very High Very High
Shock 42 99.74 Very High Very High Very High
Asthma 631 99.60 Very High Very High Very High
Heart Rate Under Development 14 99.34 Very High Very High Very High
Stress 19 99.28 Very High Very High Very High
Hypotension 28 99.08 Very High Very High Very High
Targeted Disruption 41 98.96 Very High Very High Very High
Autoimmune Disease 1 98.96 Very High Very High Very High
Coronary Artery Disease 21 98.76 Very High Very High Very High
Injury 250 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that ST2 would be increased at presentation in ED chest pain patients with myocardial ischemia, thus allowing for the early identification of acute myocardial infarction, acute coronary syndrome, and 30-day adverse cardiovascular events, with an area under the receiver operator characteristic curve (AUC) for each outcome of greater than 0.7.
Positive_regulation (increased) of ST2 in chest associated with acute coronary syndrome, angina, coronary artery disease, ischemia and myocardial infarction
1) Confidence 0.69 Published 2007 Journal Ann Emerg Med Section Abstract Doc Link 17466411 Disease Relevance 1.07 Pain Relevance 0.22
Increased ST2, a protein thought to participate in the response to cardiovascular injury, has been noted to be prognostic in patients with acute myocardial infarction.
Positive_regulation (Increased) of ST2 associated with injury and myocardial infarction
2) Confidence 0.69 Published 2007 Journal Ann Emerg Med Section Abstract Doc Link 17466411 Disease Relevance 1.02 Pain Relevance 0.20
Indeed, soluble ST2 levels are increased in the serum of patients one day after myocardial infarction.
Positive_regulation (increased) of ST2 associated with myocardial infarction
3) Confidence 0.56 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.15 Pain Relevance 0.11
It is known that ST2 directs Th2 lymphocyte function; this finding suggests that ST2 is induced in conditions of myocardial overload such as myocardial infarction, when the remaining viable myocardium must bear more stress.
Positive_regulation (induced) of ST2 in myocardium associated with stress and myocardial infarction
4) Confidence 0.56 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.08 Pain Relevance 0.12
In a post hoc analysis, patients with outlying increased ST2 values were examined to determine possible alternative causes for ST2 expression.
Positive_regulation (increased) of ST2
5) Confidence 0.40 Published 2007 Journal Ann Emerg Med Section Body Doc Link 17466411 Disease Relevance 0 Pain Relevance 0
Soluble ST2 protein levels are elevated in the sera of patients with asthmatic exacerbation, and correlate well with the severity of asthma exacerbation [307].
Positive_regulation (elevated) of ST2 associated with asthma
6) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.49 Pain Relevance 0.07
ST2 is also elevated in acute asthma [56] and autoimmune disease [57].
Positive_regulation (elevated) of ST2 associated with asthma and autoimmune disease
7) Confidence 0.13 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.20 Pain Relevance 0
Animal models of allergic asthma have demonstrated an increased accumulation of lung CD4+/ST2+ Th2 cells [309] and ST2 knockout animals have a significant decrease of the production of Th2 cytokines [302].
Positive_regulation (accumulation) of ST2 in Th2 cells associated with targeted disruption, asthma and cytokine
8) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.21 Pain Relevance 0.14
In these patients, StO2 levels of below 70% tracked with hypotension, tachycardia, and clinical shock resulted in increases in StO2 after resuscitation maneuvers (Table 1).
Positive_regulation (increases) of StO2 associated with heart rate under development, shock and hypotension
9) Confidence 0.10 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.45 Pain Relevance 0
He received 1 liter of lactated ringers (LR) with an increase in StO2 to 76% and was taken to the operating room (OR) where he underwent a right below the knee amputation and debridement and external fixator placement for a complex left tibia fracture.
Positive_regulation (increase) of StO2 in tibia associated with bone fracture and amputation
10) Confidence 0.10 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.62 Pain Relevance 0
His StO2 increased to 88%.
Positive_regulation (increased) of StO2
11) Confidence 0.07 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.61 Pain Relevance 0
The patient was taken to the OR where his abdomen was opened and a Bogota bag was placed with immediate improvement of all parameters (StO2 increased to 91%).
Positive_regulation (increased) of StO2 in abdomen
12) Confidence 0.07 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.72 Pain Relevance 0
He received 1 liter of LR with an increase of his BP to 110/70 mm Hg and StO2 to 82%.
Positive_regulation (increase) of StO2
13) Confidence 0.07 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.80 Pain Relevance 0
StO2 increased to 73%.
Positive_regulation (increased) of StO2
14) Confidence 0.07 Published 2009 Journal World J Emerg Surg Section Body Doc Link PMC2714076 Disease Relevance 0.78 Pain Relevance 0
In these patients, StO2 levels of below 70% tracked with hypotension, tachycardia, and clinical shock resulted in increases in StO2 after resuscitation maneuvers.


Positive_regulation (increases) of StO2 associated with heart rate under development, shock and hypotension
15) Confidence 0.07 Published 2009 Journal World J Emerg Surg Section Abstract Doc Link PMC2714076 Disease Relevance 0.54 Pain Relevance 0

General Comments

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