INT143673

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.81
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Anatomy Link Frequency
visceral 2
spinal nerve 2
ganglia 2
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 7 100.00 Very High Very High Very High
c fibre 17 98.20 Very High Very High Very High
Calcitonin gene-related peptide 35 81.68 Quite High
nud 2 77.36 Quite High
Visceral pain 1 77.04 Quite High
nociceptor 20 75.00 Quite High
qutenza 6 74.24 Quite High
Inflammation 3 64.08 Quite High
TRP channel 7 60.08 Quite High
dorsal root ganglion 2 57.44 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 70 83.80 Quite High
Gastritis 1 82.88 Quite High
Nociception 3 80.28 Quite High
Dyspepsia 2 77.36 Quite High
Targeted Disruption 18 65.16 Quite High
INFLAMMATION 3 64.08 Quite High
Increased Venous Pressure Under Development 2 54.80 Quite High
Apoptosis 8 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: We conclude that ASIC2 and ASIC3 channels are not directly involved in the development or maintenance of neuropathic pain after spinal nerve ligation.
Neg (not) Regulation (involved) of Gene_expression (channels) of ASIC2 in spinal nerve
1) Confidence 0.43 Published 2010 Journal Anesthesiology Section Body Doc Link 20693874 Disease Relevance 0 Pain Relevance 0
Conversely, gastroesophageal afferents are less sensitive to benzamil, and its action depends less on ASIC expression. mRNA for ASIC3 showed higher and ASIC1a showed lower relative expression in colonic afferents from thoracolumbar dorsal root ganglia than in gastric afferents from nodose (vagal) ganglia.
Regulation (depends) of Gene_expression (expression) of ASIC in ganglia associated with asic
2) Confidence 0.39 Published 2007 Journal Pain Section Abstract Doc Link 17467171 Disease Relevance 0.07 Pain Relevance 0.31
In the visceral afferent neurons of the nucleus tractus solitarii in mice, ASIC2 attenuates afferent signaling after gastric acid insult.
Regulation (afferent) of Gene_expression (attenuates) of ASIC2 in visceral
3) Confidence 0.04 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.75 Pain Relevance 0.25
Whether this is attributable to the direct regulation of ASIC expression remains to be resolved.


Regulation (regulation) of Gene_expression (expression) of ASIC associated with asic
4) Confidence 0.02 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.22

General Comments

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