INT143682

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.28
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) cell adhesion (Ada)
plasma membrane (Ada) lysosome (Ada) cytoplasm (Ada)
Ada (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 19 100.00 Very High Very High Very High
anesthesia 1 25.00 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 1 97.00 Very High Very High Very High
Asthma 1 95.16 Very High Very High Very High
Occupational Lung Diseases 1 91.24 High High
Injury 4 50.00 Quite Low
Enteropathy 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Berberine, a major ingredient of OGT, suppressed ADA expression and reduced the incidence of lethality.
Negative_regulation (suppressed) of Gene_expression (expression) of ADA
1) Confidence 0.54 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19319464 Disease Relevance 0 Pain Relevance 0
Characterization of mice with elevated adenosine levels secondary to the loss of adenosine deaminase (ADA) expression, the primary metabolic enzyme for adenosine, further support a role for this ubiquitous mediator in the pathogenesis of asthma.
Negative_regulation (loss) of Gene_expression (expression) of ADA associated with asthma and adenocard
2) Confidence 0.42 Published 2007 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 17468137 Disease Relevance 0.28 Pain Relevance 0.44
Quantitative real time RT-PCR and in situ hybridization showed that OGT decreased the expression of ADA, which possibly resulted in the elevation of the anti-inflammatory nucleoside adenosine.
Negative_regulation (decreased) of Gene_expression (expression) of ADA
3) Confidence 0.39 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19319464 Disease Relevance 0 Pain Relevance 0

General Comments

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