INT1437

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2011
Negated 4
Speculated 4
Reported most in Abstract
Documents 132
Total Number 138
Disease Relevance 35.22
Pain Relevance 60.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
plasma 21
pituitary 9
tail 6
brain 4
melanocyte 4
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 153 100.00 Very High Very High Very High
Enkephalin 151 100.00 Very High Very High Very High
tail-flick 43 100.00 Very High Very High Very High
Pain 41 100.00 Very High Very High Very High
antinociception 38 100.00 Very High Very High Very High
Serotonin 28 100.00 Very High Very High Very High
Neurotransmitter 26 100.00 Very High Very High Very High
Potency 22 100.00 Very High Very High Very High
Antinociceptive 20 100.00 Very High Very High Very High
analgesia 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 622 100.00 Very High Very High Very High
Targeted Disruption 270 100.00 Very High Very High Very High
Pain 34 100.00 Very High Very High Very High
Toxicity 5 100.00 Very High Very High Very High
Diabetes Mellitus 374 99.84 Very High Very High Very High
Adrenal Insufficiency 31 99.82 Very High Very High Very High
Obesity 268 99.80 Very High Very High Very High
Appetite Loss 34 99.62 Very High Very High Very High
Alopecia Areata 8 99.52 Very High Very High Very High
Sprains And Strains 72 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic alcohol intake significantly reduces POMC mRNA in the lobes of the pituitary.
Negative_regulation (reduces) of POMC mRNA in pituitary associated with alcohol
1) Confidence 0.59 Published 1988 Journal Alcohol Section Abstract Doc Link 2969250 Disease Relevance 0.17 Pain Relevance 0.34
Because the opioid peptide beta-endorphin is co-synthesized and released with melanocortins from proopiomelanocortin (POMC) neuronal terminals, we examined the physiological role of beta-endorphin in feeding and energy homeostasis using a strain of mutant mice with a selective deficiency of beta-endorphin.
Negative_regulation (deficiency) of beta-endorphin in neuronal associated with sprains and strains and opioid
2) Confidence 0.59 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12851316 Disease Relevance 0.29 Pain Relevance 0.24
Following treatment, POMC mRNA levels, measured by quantitative solution hybridization/RNase protection assays, were decreased by 48% in the pituitary of the TK+/+ mice, reflecting an expected loss of the pituitary corticotrope POMC cells.
Negative_regulation (decreased) of POMC mRNA in pituitary
3) Confidence 0.59 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578531 Disease Relevance 0.33 Pain Relevance 0.29
Selective reward deficit in mice lacking beta-endorphin and enkephalin.
Negative_regulation (lacking) of beta-endorphin associated with enkephalin
4) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Title Doc Link 12223579 Disease Relevance 0.09 Pain Relevance 0.90
The acute administration of methadone in nonpregnant mice produced an increase in ACTH level throughout the estrous cycle whereas subchronic treatment reduced ACTH level by 51%.
Negative_regulation (reduced) of ACTH associated with methadone
5) Confidence 0.57 Published 1983 Journal Pediatr Pharmacol (New York) Section Abstract Doc Link 6326036 Disease Relevance 0.08 Pain Relevance 0.48
In addition, the met-enkephalin and beta-endorphin level in the lymph nodes of addicted mice were also depressed.
Negative_regulation (depressed) of beta-endorphin in lymph nodes associated with enkephalin
6) Confidence 0.55 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2963224 Disease Relevance 0.10 Pain Relevance 0.27
Importantly, all subjects including those lacking both beta-endorphin and enkephalins learned to self-administer ethanol similarly to wild-type mice and maintained responding for ethanol under a variety of procedural variables.
Negative_regulation (lacking) of beta-endorphin associated with enkephalin
7) Confidence 0.54 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15388297 Disease Relevance 0.16 Pain Relevance 0.50
Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin.
Negative_regulation (lacking) of beta-endorphin associated with enkephalin
8) Confidence 0.54 Published 2004 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 15388297 Disease Relevance 0.17 Pain Relevance 0.63
Because her plasma ACTH level was not increased, a diagnosis of secondary AI (due to deficiency in ACTH) was made.
Negative_regulation (deficiency) of ACTH in plasma associated with adrenal insufficiency
9) Confidence 0.53 Published 2005 Journal JAMA Section Abstract Doc Link 16287959 Disease Relevance 1.11 Pain Relevance 0.31
In adrenalectomized mice plasma levels of ACTH were decreased by MENK.
Negative_regulation (decreased) of ACTH in plasma associated with enkephalin
10) Confidence 0.53 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1325954 Disease Relevance 0 Pain Relevance 1.15
MENK-induced inhibition of cellular functions in nonimmunized mice was associated with a decrease of plasma ACTH level, whereas MENK-induced stimulation of phagocytosis in immunized mice was paralleled with an elevation of ACTH, suggesting a role of corticoids in immunomodulation by MENK.
Negative_regulation (decrease) of ACTH in plasma associated with enkephalin
11) Confidence 0.52 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8253542 Disease Relevance 0 Pain Relevance 0.71
Postoperative investigations revealed that despite a small dose of steroid replacement for only 20 days, plasma ACTH level was decreased for a period of 6 months.
Negative_regulation (decreased) of ACTH in plasma
12) Confidence 0.51 Published 1994 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 7851619 Disease Relevance 0.82 Pain Relevance 0.07
In stressed guinea-pigs plasma beta-endorphin levels were reduced 5 min after morphine injection. 5.
Negative_regulation (reduced) of beta-endorphin in plasma associated with morphine
13) Confidence 0.50 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 2055415 Disease Relevance 0.25 Pain Relevance 0.44
In rats beta-endorphin levels were significantly reduced 24 hr post soman poisoning, but returned to control levels by 48 hr.
Negative_regulation (reduced) of beta-endorphin associated with poisoning
14) Confidence 0.47 Published 1987 Journal Life Sci. Section Abstract Doc Link 2955188 Disease Relevance 0.28 Pain Relevance 0.54
Using whole cell patch clamp recordings, orexin suppresses the spontaneous firing in these neurones, suggesting that its appetite enhancing effects include an effect in suppressing hypothalamic POMC neuronal activity [158].


Negative_regulation (suppressing) of POMC in neuronal
15) Confidence 0.47 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.16 Pain Relevance 0.19
In the STZ treated mice, POMC mRNA levels were drastically decreased by a 8 fold, whereas in the STZ subgroup receiving the insulin injection, POMC mRNA levels were reinduced by a 3.4 fold.
Negative_regulation (decreased) of POMC mRNA
16) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.16 Pain Relevance 0
Hypothalamic beta-endorphin concentrations are decreased in animals models of autoimmune disease.
Negative_regulation (decreased) of beta-endorphin associated with autoimmune disease
17) Confidence 0.46 Published 1999 Journal J. Neuroimmunol. Section Title Doc Link 10408966 Disease Relevance 1.08 Pain Relevance 0.09
RESULTS: Prior to treatment, ACTH and cortisol responses to naloxone (areas under the curve) were significantly higher in obese women then in control women (P = 0.027 and P = 0.035 respectively) dF treatment resulted in significant (P < 0.05) reduction of ACTH and cortisol increments.
Negative_regulation (reduction) of ACTH
18) Confidence 0.44 Published 1997 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 9196609 Disease Relevance 0 Pain Relevance 0
ICI 174,864 alone failed to produce either a significant increase or decrease of morphine, phenazocine, etorphine or beta-endorphin antinociception.
Negative_regulation (decrease) of beta-endorphin associated with antinociception, immobilon and morphine
19) Confidence 0.44 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2548877 Disease Relevance 0 Pain Relevance 2.03
The effect of food and water deprivation on post-stress analgesia in mice and levels of beta-endorphin and dynorphin in blood plasma and hypothalamus.
Negative_regulation (deprivation) of beta-endorphin in blood associated with stress, dynorphin, narcan and analgesia
20) Confidence 0.43 Published 1985 Journal Arch. Int. Physiol. Biochim. Section Title Doc Link 2421664 Disease Relevance 0.29 Pain Relevance 0.63

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