INT143713

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.38
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 60 95.76 Very High Very High Very High
ischemia 2 91.60 High High
chemokine 10 85.00 Quite High
cytokine 24 84.40 Quite High
addiction 3 82.84 Quite High
headache 1 71.80 Quite High
antagonist 19 66.32 Quite High
metalloproteinase 5 47.76 Quite Low
Inflammatory response 2 47.00 Quite Low
Arthritis 2 46.40 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 53 95.76 Very High Very High Very High
Disease 46 90.72 High High
Pulmonary Disease 107 89.64 High High
Death 3 75.72 Quite High
Shock 2 75.00 Quite High
Stroke 2 75.00 Quite High
Encephalitis 2 74.08 Quite High
Headache 1 71.80 Quite High
Anaemia 1 71.40 Quite High
Middle Cerebral Artery Infarction 1 53.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B kinaseß (IKKß); activation of the TAB1-TAB2-TAK1 complex by ubiquitylated TRAF6, also leading to phosphorylation and activation of IKKß, and phosphorylation of I-?
Positive_regulation (activation) of Phosphorylation (phosphorylation) of IKK
1) Confidence 0.25 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.04
B kinaseß (IKKß); activation of the TAB1-TAB2-TAK1 complex by ubiquitylated TRAF6, also leading to phosphorylation and activation of IKKß, and phosphorylation of I-?
Positive_regulation (leading) of Phosphorylation (phosphorylation) of IKK
2) Confidence 0.25 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.04
Co-immunoprecipitation studies revealed an interaction of Hsp70 with NF-kappaB and IkappaBalpha, but not with IkappaB kinase, IKKgamma, suggesting that Hsp70 binds to the NF-kappaB:IkappaB complex preventing IkappaB phosphorylation by IKK.
Positive_regulation (preventing) of Phosphorylation (phosphorylation) of IKK
3) Confidence 0.18 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.71 Pain Relevance 0.26
B kinase (IKK)-dependent phosphorylation undergoes ubiquitin-mediated proteolysis thus resulting in the release of active NF-?
Positive_regulation (undergoes) of Phosphorylation (phosphorylation) of IKK
4) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.67 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox