INT143714

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.94
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
mononuclear cells 1
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 3 99.04 Very High Very High Very High
Inflammation 52 98.40 Very High Very High Very High
fibrosis 29 97.72 Very High Very High Very High
cytokine 9 83.44 Quite High
ischemia 2 67.44 Quite High
Inflammatory response 5 59.84 Quite High
Analgesic 2 25.00 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 2 99.04 Very High Very High Very High
INFLAMMATION 48 98.40 Very High Very High Very High
Fibrosis 11 97.72 Very High Very High Very High
Apoptosis 10 95.84 Very High Very High Very High
Hemophilus Infection 89 93.36 High High
Occupational Lung Diseases 54 91.24 High High
Targeted Disruption 21 89.76 High High
Death 2 88.56 High High
Encephalitis 2 86.92 High High
Infection 12 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(NFKBIA) phosphorylation significantly decreases silica induced inflammation and fibrosis, with reduced collagen deposition and apoptosis.
Phosphorylation (phosphorylation) of NFKBIA associated with fibrosis, inflammation and apoptosis
1) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 1.34 Pain Relevance 0.15
This was associated with decreased phosphorylation of NF-kappaB inhibitor protein, IkappaBalpha, and decreased expression of several NFkappaB-regulated genes.
Phosphorylation (phosphorylation) of IkappaBalpha
2) Confidence 0.61 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.88 Pain Relevance 0.29
Indeed, there are still increasing evidences that the blockade of MAPK inhibited NF-kappa B-dependent gene transcription without affecting IkappaBalpha phosphorylation and NF-kappa B-DNA binding ability [9,24-27].
Phosphorylation (phosphorylation) of IkappaBalpha
3) Confidence 0.22 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.28 Pain Relevance 0.04
Also, we detected the I-kappaBalpha phosphorylation and the p65NF-kappaB expression in peripheral blood mononuclear cells under our experimental condition.
Phosphorylation (phosphorylation) of I-kappaBalpha in mononuclear cells
4) Confidence 0.07 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.44 Pain Relevance 0.38

General Comments

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