INT143716

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.25
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 274 95.76 Very High Very High Very High
cytokine 101 94.56 High High
ischemia 6 91.60 High High
Inflammatory response 39 88.48 High High
Inflammatory mediators 7 88.48 High High
chemokine 52 85.00 Quite High
cINOD 13 83.28 Quite High
addiction 3 82.40 Quite High
tolerance 3 81.00 Quite High
Potency 18 80.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 110 96.16 Very High Very High Very High
INFLAMMATION 321 95.76 Very High Very High Very High
Disease 90 90.72 High High
Myeloid Leukemia 5 89.76 High High
Pulmonary Disease 251 89.64 High High
Death 25 88.28 High High
Infection 168 85.84 High High
Adhesions 21 84.80 Quite High
Necrosis 17 84.28 Quite High
Cancer 213 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B kinaseß (IKKß); activation of the TAB1-TAB2-TAK1 complex by ubiquitylated TRAF6, also leading to phosphorylation and activation of IKKß, and phosphorylation of I-?
Phosphorylation (phosphorylation) of IKK
1) Confidence 0.41 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.04
IKK, in turn, phosphorylates the I?
Phosphorylation (phosphorylates) of IKK
2) Confidence 0.30 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.98 Pain Relevance 0.04
Co-immunoprecipitation studies revealed an interaction of Hsp70 with NF-kappaB and IkappaBalpha, but not with IkappaB kinase, IKKgamma, suggesting that Hsp70 binds to the NF-kappaB:IkappaB complex preventing IkappaB phosphorylation by IKK.
Phosphorylation (phosphorylation) of IKK
3) Confidence 0.30 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.66 Pain Relevance 0.24
B activation and also suggest a model in which B14 inhibits activation of the IKK complex by preventing phosphorylation of IKK?
Phosphorylation (phosphorylation) of IKK
4) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
(Figure 3) and inhibited phosphorylation of IKK?
Phosphorylation (phosphorylation) of IKK
5) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
In summary, VACV virulence factor B14 inhibits the IKK signalosome by preventing phosphorylation of IKK?
Phosphorylation (phosphorylation) of IKK
6) Confidence 0.22 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.24 Pain Relevance 0.08
-activated kinase-1 (TAK1), which phosphorylates IKK?
Phosphorylation (phosphorylates) of IKK
7) Confidence 0.19 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.54 Pain Relevance 0.25
, phospho-IKK?
Phosphorylation (phospho) of IKK
8) Confidence 0.19 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.05 Pain Relevance 0
no phospho-IKK?
Phosphorylation (phospho) of IKK
9) Confidence 0.19 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
B activation by preventing phosphorylation of IKK?
Phosphorylation (phosphorylation) of IKK
10) Confidence 0.17 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.26 Pain Relevance 0.11
protein with mutations at serine-32 and 36 is not phosphorylated by IKK (I?
Neg (not) Phosphorylation (phosphorylated) of IKK
11) Confidence 0.13 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.52 Pain Relevance 0.13
B kinase (IKK), which can phosphorylate I?
Phosphorylation (phosphorylate) of IKK
12) Confidence 0.12 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0
B kinase (IKK)-dependent phosphorylation undergoes ubiquitin-mediated proteolysis thus resulting in the release of active NF-?
Phosphorylation (phosphorylation) of IKK
13) Confidence 0.07 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.66 Pain Relevance 0.23
B by decreasing phosphorylation of IKK and I?
Phosphorylation (phosphorylation) of IKK
14) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.48 Pain Relevance 0
B is phosphorylated by a kinase called IKK [38].
Phosphorylation (phosphorylated) of IKK
15) Confidence 0.03 Published 2003 Journal Crit Care Section Body Doc Link PMC270667 Disease Relevance 0.86 Pain Relevance 0.19
B kinase (IKK) activity, by limiting the phosphorylation of its catalytic subunit IKK?
Phosphorylation (phosphorylation) of IKK
16) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.04

General Comments

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