INT143719

Context Info Confidence 0.43 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.31 Pain Relevance 0.68

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia) enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)

Anatomy Link Frequency mononuclear cells 2 Nfkbia (Mus musculus)

Pain Link Frequency Relevance Heat Angina 3 99.56 Inflammation 12 92.08 ischemia 2 69.52 Inflammatory response 1 57.92 Analgesic 2 25.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 2 99.56 INFLAMMATION 7 92.08 Death 1 86.64 Encephalitis 2 85.00 Shock 2 75.00 Stroke 2 75.00 Stable Angina Pectoris 1 75.00 Middle Cerebral Artery Infarction 1 64.68 Brain Hemorrhage 2 61.04 Increased Venous Pressure Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This was associated with decreased phosphorylation of NF-kappaB inhibitor protein, IkappaBalpha, and decreased expression of several NFkappaB-regulated genes.

Negative_regulation (decreased) of Gene_expression (expression) of IkappaBalpha

1) Confidence 0.43 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.87 Pain Relevance 0.29

Also, we detected the I-kappaBalpha phosphorylation and the p65NF-kappaB expression in peripheral blood mononuclear cells under our experimental condition.

Negative_regulation (detected) of Gene_expression (expression) of I-kappaBalpha in mononuclear cells

2) Confidence 0.04 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.44 Pain Relevance 0.39

General Comments

This test has worked.