INT143719

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
mononuclear cells 2
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 3 99.56 Very High Very High Very High
Inflammation 12 92.08 High High
ischemia 2 69.52 Quite High
Inflammatory response 1 57.92 Quite High
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 2 99.56 Very High Very High Very High
INFLAMMATION 7 92.08 High High
Death 1 86.64 High High
Encephalitis 2 85.00 Quite High
Shock 2 75.00 Quite High
Stroke 2 75.00 Quite High
Stable Angina Pectoris 1 75.00 Quite High
Middle Cerebral Artery Infarction 1 64.68 Quite High
Brain Hemorrhage 2 61.04 Quite High
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was associated with decreased phosphorylation of NF-kappaB inhibitor protein, IkappaBalpha, and decreased expression of several NFkappaB-regulated genes.
Negative_regulation (decreased) of Gene_expression (expression) of IkappaBalpha
1) Confidence 0.43 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.87 Pain Relevance 0.29
Also, we detected the I-kappaBalpha phosphorylation and the p65NF-kappaB expression in peripheral blood mononuclear cells under our experimental condition.
Negative_regulation (detected) of Gene_expression (expression) of I-kappaBalpha in mononuclear cells
2) Confidence 0.04 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.44 Pain Relevance 0.39

General Comments

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