INT143743

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.42
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
VAT 4
lymphocyte 2
PC-3 2
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 152 98.40 Very High Very High Very High
cytokine 16 96.28 Very High Very High Very High
Cannabinoid 56 93.92 High High
Pain 6 85.56 High High
dexamethasone 4 80.04 Quite High
Analgesic 1 78.28 Quite High
Hippocampus 12 54.28 Quite High
Inflammation 6 47.12 Quite Low
antagonist 4 44.16 Quite Low
agonist 6 41.80 Quite Low
Disease Link Frequency Relevance Heat
Obesity 274 100.00 Very High Very High Very High
Cancer 350 99.56 Very High Very High Very High
Prostate Cancer 225 96.68 Very High Very High Very High
Teratocarcinoma 8 93.56 High High
Apoptosis 32 92.92 High High
Glioma 9 88.16 High High
Anxiety Disorder 2 86.04 High High
Pain 6 85.56 High High
Glioblastoma 4 83.16 Quite High
Carcinoma 4 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report the successful overexpression of rat and human FAAH as a fusion to the E. coli maltose-binding protein, retaining catalytic properties of native FAAH.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FAAH
1) Confidence 0.60 Published 2008 Journal Amino Acids Section Abstract Doc Link 17476568 Disease Relevance 0.17 Pain Relevance 0.12
However, the production of high amounts of enzyme is hampered by the known refractiveness of FAAH to overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FAAH
2) Confidence 0.50 Published 2008 Journal Amino Acids Section Abstract Doc Link 17476568 Disease Relevance 0.17 Pain Relevance 0.13
However, and at variance with the lymphocyte study of [26], we did not observe any obvious increase in FAAH protein levels following IL-4 treatment, although as a caveat it should be pointed out that the Western blot protocol we used was not fully optimised.
Positive_regulation (increase) of Gene_expression (levels) of FAAH protein in lymphocyte
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.77 Pain Relevance 0.10
However, transfection of PC-3 cells with FAAH does increase their rate of 2-AG hydrolysis in addition to the effects on AEA hydrolysis [12].
Positive_regulation (transfection) of Gene_expression (transfection) of FAAH in PC-3
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.35 Pain Relevance 0.08
Interleukin-4 (IL-4) stimulation of FAAH activity in cultured cancer cells
Positive_regulation (stimulation) of Gene_expression (activity) of FAAH associated with cancer
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.31 Pain Relevance 0.04
Why is FAAH-IR expression higher in tumour tissue than in the normal prostate
Positive_regulation (Why) of Gene_expression (expression) of FAAH associated with cancer
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.75 Pain Relevance 0.12
In fact, a lower expression of the fatty acid amide hydrolase (FAAH), which can metabolise both AEA and 2-AG, as well as other congeners of AEA (see below), or of the monoacylglycerol lipase (MAGL), which is more specific for 2-AG [15], has been reported in the VAT of obese individuals [10,16], possibly accounting for the observed higher VAT levels of 2-AG [3].
Spec (possibly) Positive_regulation (accounting) of Gene_expression (expression) of FAAH in VAT associated with obesity
7) Confidence 0.28 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.93 Pain Relevance 0.27
In fact, a lower expression of the fatty acid amide hydrolase (FAAH), which can metabolise both AEA and 2-AG, as well as other congeners of AEA (see below), or of the monoacylglycerol lipase (MAGL), which is more specific for 2-AG [15], has been reported in the VAT of obese individuals [10,16], possibly accounting for the observed higher VAT levels of 2-AG [3].
Positive_regulation (metabolise) of Gene_expression (expression) of acid amide hydrolase in VAT associated with obesity
8) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.54 Pain Relevance 0.26
An increase in the local endocannabinoid concentration (by blockade of their metabolism) results in a reduced invasivity of the cells in vitro, whilst reduction of 2-arachidonoylglycerol synthesis, blockade of CB1 receptors, or an increased expression of the anandamide metabolising enzyme fatty acid amide hydrolase produces the reverse pattern [10], [11].
Positive_regulation (increased) of Gene_expression (expression) of fatty acid amide hydrolase associated with endocannabinoid
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 0.43 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox