INT143744

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 14
Disease Relevance 8.42
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
lymphocytes 1
colons 1
epithelial cell 1
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 205 100.00 Very High Very High Very High
Cannabinoid receptor 9 100.00 Very High Very High Very High
cytokine 36 99.12 Very High Very High Very High
Pain 12 98.68 Very High Very High Very High
Analgesic 5 96.32 Very High Very High Very High
Inflammation 37 94.80 High High
antagonist 12 87.12 High High
Cannabinoid 109 86.04 High High
IPN 1 85.28 High High
agonist 6 55.20 Quite High
Disease Link Frequency Relevance Heat
Disease 248 100.00 Very High Very High Very High
Cancer 695 99.68 Very High Very High Very High
Malignant Neoplastic Disease 108 98.96 Very High Very High Very High
Pain 12 98.68 Very High Very High Very High
Prostate Cancer 459 98.36 Very High Very High Very High
Anxiety Disorder 1 98.32 Very High Very High Very High
Inflammatory Bowel Disease 54 98.08 Very High Very High Very High
Colitis 20 96.52 Very High Very High Very High
INFLAMMATION 34 94.80 High High
Pancreatic Cancer 27 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fatty acid amide hydrolase (FAAH), a membrane-anchored enzyme responsible for the termination of endocannabinoid signalling, is an attractive target for treating conditions such as pain and anxiety.
Regulation (target) of FAAH associated with pain, endocannabinoid and anxiety disorder
1) Confidence 0.61 Published 2008 Journal Amino Acids Section Abstract Doc Link 17476568 Disease Relevance 0.20 Pain Relevance 0.15
In prostate cancer, the predominant epithelial cell type stains for markers of luminal cells [40], and our finding that the median FAAH-IR in the epithelial tumour cells was higher than in the luminal cells in the non-malignant cores would be consistent with the notion of an up-regulation of FAAH in the tumour tissue.
Regulation (regulation) of FAAH in epithelial cell associated with malignant neoplastic disease, cancer and prostate cancer
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 1.05 Pain Relevance 0
It is well known that the tumour microenvironment plays an important role in the pathogenesis of prostate cancer [63], and it can be hypothesised that a component of the tumour microenvironment regulates in the same manner the activity of both CB1 receptors and FAAH.
Regulation (regulates) of FAAH associated with cancer and prostate cancer
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.57 Pain Relevance 0.11
There were also no changes in mRNA levels for FAAH in either PC3 or LNCaP cells following incubation with IL-4 for either 3 or 24 h.
Regulation (changes) of FAAH
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.89 Pain Relevance 0.04
Thus, the FAAH-IR correlates with disease severity at diagnosis, despite the fact that the median FAAH-IR scores for each Gleason group are not that different (2 (n?
Regulation (different) of FAAH associated with disease
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.75 Pain Relevance 0
A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K(i) 21.8 microM) without significantly affecting FAAH.
Neg (without) Regulation (affecting) of FAAH
6) Confidence 0.26 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 18819796 Disease Relevance 0.17 Pain Relevance 0.34
Importantly for the co-variance argument raised above, IL-4 also increases the expression of CB1 receptors in lymphocytes [27], [28] so we elected to focus on that molecule as a “test of concept” that a component of the tumour microenvironment can influence FAAH activity.
Regulation (influence) of FAAH in lymphocytes associated with cancer
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.79 Pain Relevance 0.11
A case is made that the FAAH-IR is regulated by the tumour microenvironment, and a potential candidate molecule, IL-4, has been investigated in vitro, although contributions by other components of the tumour environment should certainly be considered.
Regulation (regulated) of FAAH associated with cancer
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 1.03 Pain Relevance 0.06
For readers unfamiliar with the statistical methods used to assess the influence of FAAH-IR upon disease outcome, a brief explanation of their usefulness is warranted, particularly with respect to the choice of cutoff values for FAAH-IR.
Regulation (influence) of FAAH associated with disease
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.63 Pain Relevance 0
To our knowledge the only molecules known to regulate FAAH activity are the TH1 cytokines IL-12 and IFN?
Regulation (regulate) of FAAH associated with cytokine
10) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.62 Pain Relevance 0.13
In consequence, in the present study, we have investigated the FAAH-IR in the tissue microarray used previously by us to characterise CB1IR in the tumour tissue [14], and undertaken studies using cultured cells to see if a known component of the tumour microenvironment can affect the FAAH activity.
Regulation (affect) of FAAH associated with cancer
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.84 Pain Relevance 0
These data suggest a dysregulated AEA tone in the colon of these patients, in agreement with previous findings.[20], [25] However, we observed low NAPE-PLD expression, mainly in moderate and severe-scored pancolitis patients, and no changes in the AEA-degrading enzyme FAAH, suggesting a decrease of AEA levels, as deduced by the NAPE-PLD/FAAH ratio, while D-Argenio et al. found high AEA levels in biopsy samples of colons from untreated UC patients.[25] This discrepancy may be explained by the fact that NAPE-PLD is not the only source for AEA, as others enzymes are also capable of generating AEA from NAPE, such as ?
Neg (no) Regulation (changes) of FAAH in colons associated with inflammatory bowel disease
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.18 Pain Relevance 0.23
Higher levels of FAAH immunoreactivity were measured in quiescent samples of moderate UC patients compared with acute [55.78±2.15 vs 50.79±1.80 (×103); p<0.05] and control samples [55.78±2.15 vs 51.01±1.63 (×103); p<0.05].
Regulation (immunoreactivity) of FAAH associated with inflammatory bowel disease
13) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.64 Pain Relevance 0
Immunoreactivity for CB1, NAPE-PLD, and FAAH was localized in the postacrosomal region and in the midpiece, whereas for TRPV1, it was restricted to the postacrosomal region.
Regulation (Immunoreactivity) of FAAH associated with cannabinoid receptor
14) Confidence 0.11 Published 2009 Journal Endocrinology Section Abstract Doc Link 19608651 Disease Relevance 0.05 Pain Relevance 0.38

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