INT143747

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 4.05
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, LEP) extracellular region (IL6, LEP) aging (IL6)
lipid metabolic process (LEP)
IL6 (Homo sapiens)
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 18 90.28 High High
Inflammation 32 82.16 Quite High
cytokine 37 80.20 Quite High
spinal inflammation 4 50.00 Quite Low
Inflammatory response 6 39.08 Quite Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 174 93.60 High High
Apnoea 534 93.24 High High
Impaired Glucose Tolerance 30 90.28 High High
INFLAMMATION 42 82.16 Quite High
Diabetes Mellitus 96 78.72 Quite High
Insulin Resistance 78 74.12 Quite High
Hyperglycemia 6 73.32 Quite High
Hyperinsulinism 12 73.20 Quite High
Glucose Metabolism Disorders 6 64.12 Quite High
Coronary Heart Disease 6 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the IL-6 in the case group was strongly positively associated with BMI and leptin-to-leptin receptor ratio.
IL-6 Binding (associated) of leptin
1) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.28 Pain Relevance 0.04
Importantly, our results further showed additional close associations of IL-6 with BMI and leptin-to-leptin receptor ratio in IGM.
IL-6 Binding (associations) of leptin
2) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.62 Pain Relevance 0.12
Furthermore, the IL-6 in the case group was strongly positively associated with BMI and leptin-to-leptin receptor ratio.
IL-6 Binding (associated) of leptin
3) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.28 Pain Relevance 0.04
Importantly, our results further showed additional close associations of IL-6 with BMI and leptin-to-leptin receptor ratio in IGM.
IL-6 Binding (associations) of leptin
4) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.62 Pain Relevance 0.12
In the case group, the IL-6 was positively linearly associated with leptin-to-leptin receptor ratio, BMI, and LowSaO2 or AHI (both P < 0.001).
IL-6 Binding (associated) of leptin
5) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.12 Pain Relevance 0.03
In the case group, the IL-6 was positively linearly associated with leptin-to-leptin receptor ratio, BMI, and LowSaO2 or AHI (both P < 0.001).
IL-6 Binding (associated) of leptin
6) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.12 Pain Relevance 0.03
CONCLUSION: Serum leptin/BMI levels were increased and significantly associated with IL-6 levels and disease activity in men with AS, suggesting a possible role for leptin in the inflammatory reactions of AS.


IL-6 Binding (associated) of leptin
7) Confidence 0.02 Published 2007 Journal Scand. J. Rheumatol. Section Body Doc Link 17476615 Disease Relevance 0 Pain Relevance 0

General Comments

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