INT143763

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.72
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) protein folding (St13) cytosol (St13)
protein complex (St13) cytoplasm (St13)
Anatomy Link Frequency
neurons 1
St13 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 5 99.76 Very High Very High Very High
Enkephalin 28 98.72 Very High Very High Very High
Eae 1 98.64 Very High Very High Very High
Analgesic 23 97.76 Very High Very High Very High
cocaine 7 97.56 Very High Very High Very High
allodynia 16 96.60 Very High Very High Very High
Thermal hyperalgesia 4 96.04 Very High Very High Very High
agonist 232 94.12 High High
Pain 56 93.20 High High
opioid receptor 28 72.48 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 16 96.60 Very High Very High Very High
Hyperalgesia 20 96.04 Very High Very High Very High
Pain 60 93.20 High High
Neuroblastoma 12 65.68 Quite High
Targeted Disruption 24 30.84 Quite Low
Inflammatory Pain 32 25.32 Quite Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hop extracts exhibited a significant pharmacological interaction with paracetamol, with the most pronounced increase in analgesic action being found for the ethanolic extract of Aroma hops and the tert-butanolic extract of wild hops.
Hop Binding (interaction) of associated with paracetamol and analgesic
1) Confidence 0.36 Published 2007 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 17479542 Disease Relevance 0 Pain Relevance 1.01
In contrast, SNC80 may interact differentially with the receptor binding pocket to promote a distinct active conformation, which in turn triggers signaling, as well as receptor phosphorylation and internalization.
SNC80 Binding (interact) of
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.09 Pain Relevance 0.22
As seen previously, a subsequent injection of SNC80 was ineffective, but repeated injection of ARM390 continued to attenuate mechanical allodynia and thermal hyperalgesia (Figure 2D, Test 2).
SNC80 Binding (injection) of associated with allodynia and thermal hyperalgesia
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.50 Pain Relevance 0.51
SNC80 and ARM390 differentially internalize the DOR-eGFP receptor in live neurons
SNC80 Binding (internalize) of in neurons
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.06 Pain Relevance 0.63
SNC80 and ARM390 therefore bind to and activate the DOR-eGFP receptor with comparable potencies and efficacies.


SNC80 Binding (bind) of
5) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox