INT143763
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Hop extracts exhibited a significant pharmacological interaction with paracetamol, with the most pronounced increase in analgesic action being found for the ethanolic extract of Aroma hops and the tert-butanolic extract of wild hops. | |||||||||||||||
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In contrast, SNC80 may interact differentially with the receptor binding pocket to promote a distinct active conformation, which in turn triggers signaling, as well as receptor phosphorylation and internalization. | |||||||||||||||
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As seen previously, a subsequent injection of SNC80 was ineffective, but repeated injection of ARM390 continued to attenuate mechanical allodynia and thermal hyperalgesia (Figure 2D, Test 2). | |||||||||||||||
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SNC80 and ARM390 differentially internalize the DOR-eGFP receptor in live neurons | |||||||||||||||
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SNC80 and ARM390 therefore bind to and activate the DOR-eGFP receptor with comparable potencies and efficacies.
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General Comments
This test has worked.