INT143763

Context Info Confidence 0.36 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 0.72 Pain Relevance 3.01

unfolded protein binding (St13) protein folding (St13) cytosol (St13) protein complex (St13) cytoplasm (St13)

Anatomy Link Frequency neurons 1 St13 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 5 99.76 Enkephalin 28 98.72 Eae 1 98.64 Analgesic 23 97.76 cocaine 7 97.56 allodynia 16 96.60 Thermal hyperalgesia 4 96.04 agonist 232 94.12 Pain 56 93.20 opioid receptor 28 72.48

Disease Link Frequency Relevance Heat Neuropathic Pain 16 96.60 Hyperalgesia 20 96.04 Pain 60 93.20 Neuroblastoma 12 65.68 Targeted Disruption 24 30.84 Inflammatory Pain 32 25.32 INFLAMMATION 8 5.00 Decapitation 4 5.00 Stress 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hop extracts exhibited a significant pharmacological interaction with paracetamol, with the most pronounced increase in analgesic action being found for the ethanolic extract of Aroma hops and the tert-butanolic extract of wild hops.

Hop Binding (interaction) of associated with paracetamol and analgesic

1) Confidence 0.36 Published 2007 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 17479542 Disease Relevance 0 Pain Relevance 1.01

In contrast, SNC80 may interact differentially with the receptor binding pocket to promote a distinct active conformation, which in turn triggers signaling, as well as receptor phosphorylation and internalization.

SNC80 Binding (interact) of

2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.09 Pain Relevance 0.22

As seen previously, a subsequent injection of SNC80 was ineffective, but repeated injection of ARM390 continued to attenuate mechanical allodynia and thermal hyperalgesia (Figure 2D, Test 2).

SNC80 Binding (injection) of associated with allodynia and thermal hyperalgesia

3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.50 Pain Relevance 0.51

SNC80 and ARM390 differentially internalize the DOR-eGFP receptor in live neurons

SNC80 Binding (internalize) of in neurons

4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.06 Pain Relevance 0.63

SNC80 and ARM390 therefore bind to and activate the DOR-eGFP receptor with comparable potencies and efficacies.

SNC80 Binding (bind) of

5) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.63

General Comments

This test has worked.