INT143767

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 12.34
Pain Relevance 10.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
neurons 4
nerve 2
olfactory system 1
cornea 1
Trpm8 (Mus musculus)
Trpm8 - Y745H (1)
Pain Link Frequency Relevance Heat
antagonist 202 99.92 Very High Very High Very High
Potency 24 99.92 Very High Very High Very High
allodynia 225 99.60 Very High Very High Very High
trigeminal ganglion 150 99.18 Very High Very High Very High
imagery 101 99.04 Very High Very High Very High
calcitonin gene related peptide 46 98.72 Very High Very High Very High
qutenza 61 98.28 Very High Very High Very High
addiction 37 97.98 Very High Very High Very High
dorsal root ganglion 91 97.96 Very High Very High Very High
Acute pain 12 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 646 99.60 Very High Very High Very High
Neuropathic Pain 594 99.60 Very High Very High Very High
Ganglion Cysts 283 99.18 Very High Very High Very High
Nervous System Injury 195 99.12 Very High Very High Very High
Pain 579 97.60 Very High Very High Very High
Injury 305 93.04 High High
Nociception 122 90.20 High High
Hypersensitivity 81 89.52 High High
INFLAMMATION 78 87.92 High High
Inflammatory Pain 30 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcium imaging experiments revealed that the mutation affected the ability of the antagonists to inhibit TRPM8 activity to a varying extent.
Negative_regulation (inhibit) of TRPM8 associated with antagonist and imagery
1) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.17
Furthermore, both TRPM8 and TRPV1 are inhibited by compounds such as BCTC, CTPC, SB-452533, capsazepine and ruthenium red [24,29].
Negative_regulation (inhibited) of TRPM8
2) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.14
Our results provide direct clues for the identification of different structural motifs required for antagonist binding, aiding in the design of new candidate molecules for specific inhibition of TRPM8 channels.
Negative_regulation (inhibition) of TRPM8 associated with antagonist
3) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.14
We show that mice lacking TRPM8 have severe behavioral deficits in response to cold stimuli.
Negative_regulation (lacking) of TRPM8
4) Confidence 0.43 Published 2007 Journal Neuron Section Abstract Doc Link 17481391 Disease Relevance 0.07 Pain Relevance 0.05
However, mice lacking TRPM8 behaved similarly to wild-type animals that did not have the benefit of a cool (24°C) surface.
Negative_regulation (lacking) of TRPM8
5) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0.91 Pain Relevance 1.29
One hopes that behavioral responses from mice lacking both TRPM8 and TRPA1 will demonstrate whether TRPA1 is involved in noxious cold sensing.
Negative_regulation (lacking) of TRPM8
6) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0.77 Pain Relevance 1.08
But while these explanations remain plausible in vivo, they do not explain the functional data from neuronal cultures that demonstrate cold responses even in single neurons lacking TRPM8.
Negative_regulation (lacking) of TRPM8 in neurons
7) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0 Pain Relevance 0
However, mice lacking TRPM8 no longer display this avoidance, and spend approximately equal times in both warm and cool thermal zones.
Negative_regulation (lacking) of TRPM8
8) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0.30 Pain Relevance 0.15
Although all three studies report that TRPM8-nulls are deficient in avoiding certain temperatures, discrepancies exist as to the exact temperature ranges affected.
Negative_regulation (deficient) of TRPM8
9) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0.14 Pain Relevance 0.12
In a previous study we showed that calcium imaging provides a reliable estimate of the potency of block of TRPM8 by different antagonists [26].
Negative_regulation (block) of TRPM8 associated with antagonist, imagery and potency
10) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.34
Peak cold allodynia was inhibited by capsazepine, a blocker of both TRPM8 and heat-activated TRPV1, but not by 5'-iodoresiniferatoxin, a TRPV1 blocker.
Negative_regulation (blocker) of TRPM8 associated with allodynia
11) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.51 Pain Relevance 0.54
We next proceeded to investigate the ability of several known TRPM8 antagonists to block the TRPM8-Y745H mutant channel during activation by cold.
Spec (investigate) Negative_regulation (block) of TRPM8-Y745H (Y745H) associated with antagonist
12) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.18
Overall, our data suggest a sequential model of TRPM8 gating where chemical modulators can favour (e.g. menthol) or hinder (e.g.
Negative_regulation (model) of TRPM8
13) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.18
A significant negative across strains correlation was seen between the degree of down-regulation of Trpm8 and heat allodynia (rS = -0.98, p = 0.005; rP = -0.90, p = 0.04).
Negative_regulation (regulation) of Trpm8 associated with allodynia and sprains and strains
14) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.08 Pain Relevance 0.41
That is, all of the methods showed marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 with lesser and variable change in P2rx3 and Trpv1.
Negative_regulation (regulation) of Trpm8
15) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.61 Pain Relevance 0.28
Like Trpa1, Trpm8 was strongly down-regulated in the L5DRG in all strains at 3 dpo, with expression nearly abolished in some strains (Fig. 1).
Negative_regulation (down) of Trpm8 associated with sprains and strains
16) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.17 Pain Relevance 0.38
Axotomy induced marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 in all 5 strains with lesser and variable change observed for P2rx3 and Trpv1 (Fig. 1).
Negative_regulation (regulation) of Trpm8 associated with sprains and strains
17) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.08 Pain Relevance 0.53
Distribution of TRPV1-4, TRPM5, TRPM8, and TRPA1 in mouse OE
Negative_regulation (Distribution) of TRPM8
18) Confidence 0.41 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0
Our in situ hybridization data is in broad agreement with our qRT-PCR data and shows that TRPM8 and TRPA1 mRNA are down-regulated in the DRG following nerve injury.
Negative_regulation (down) of TRPM8 in nerve associated with nervous system injury
19) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.70 Pain Relevance 0.29
Our in situ hybridization data is in broad agreement with our qRT-PCR data and shows that TRPM8 and TRPA1 mRNA are down-regulated in the DRG following nerve injury.
Negative_regulation (regulated) of TRPM8 in nerve associated with nervous system injury
20) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.70 Pain Relevance 0.29

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