INT143768

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.57
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
neurons 2
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 17 95.16 Very High Very High Very High
imagery 5 87.12 High High
TRP channel 9 76.48 Quite High
Hyperalgesia 24 65.84 Quite High
qutenza 9 53.76 Quite High
sodium channel 2 50.96 Quite High
Lasting pain 1 41.92 Quite Low
Inflammation 14 38.88 Quite Low
Nav1.7 3 38.76 Quite Low
nav1.8 1 36.36 Quite Low
Disease Link Frequency Relevance Heat
Pain 16 95.16 Very High Very High Very High
Injury 5 84.96 Quite High
Pressure And Volume Under Development 3 72.96 Quite High
Helminth Infection 1 67.36 Quite High
Hyperalgesia 28 65.84 Quite High
Nociception 8 52.32 Quite High
INFLAMMATION 12 38.88 Quite Low
Erythermalgia 1 24.84 Low Low
Neuropathic Pain 4 19.92 Low Low
Burns 1 14.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that sensory neurons derived from TRPM8 null mice lack detectable levels of TRPM8 mRNA and protein and that the number of these neurons responding to cold (18 degrees C) and menthol (100 microM) is greatly decreased.
Negative_regulation (decreased) of Positive_regulation (levels) of TRPM8 in neurons
1) Confidence 0.43 Published 2007 Journal Neuron Section Abstract Doc Link 17481392 Disease Relevance 0.18 Pain Relevance 0.17
It is also worth noting that TRPM8 responses to cold are abolished by phospholipase A2 (PLA2) inhibitors and sensitized by PLA2 products such as lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylinositol, and lysophosphatidylserine) [84].
Negative_regulation (abolished) of Positive_regulation (responses) of TRPM8
2) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0.14 Pain Relevance 0.03
M, AP18 was unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8 (Figure 2).
Negative_regulation (block) of Positive_regulation (activation) of TRPM8
3) Confidence 0.21 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.25 Pain Relevance 0.37

General Comments

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