INT143807

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.93
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc2) ATPase activity (Abcc2) transmembrane transport (Abcc2)
Anatomy Link Frequency
plasma 3
Abcc2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 30 98.08 Very High Very High Very High
diclofenac 18 95.56 Very High Very High Very High
Cancer pain 2 94.08 High High
rheumatoid arthritis 2 92.44 High High
Perioperative pain 2 91.56 High High
Inflammation 2 88.96 High High
Morphine 3 88.44 High High
Analgesic 2 88.08 High High
Versed 12 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 3 99.52 Very High Very High Very High
Cancer Pain 2 94.08 High High
Rheumatoid Arthritis 2 92.44 High High
Post Operative Pain 2 91.56 High High
INFLAMMATION 2 88.96 High High
Hepatotoxicity 4 33.36 Quite Low
Arrhythmia Under Development 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Renal Failure 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that loss of multidrug resistance protein 2 (MRP2/ABCC2) and breast cancer resistance protein (BCRP/ABCG2) in mice results in highly increased plasma levels of diclofenac acyl glucuronide, after both oral and intravenous administration.
Negative_regulation (loss) of multidrug resistance protein 2 in plasma associated with breast cancer and diclofenac
1) Confidence 0.58 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.47 Pain Relevance 0.60
Combined loss of Mrp2 and Mrp3 leads to a substantial accumulation of M3G in the liver, from which it is transported across the sinusoidal membrane at a low rate, resulting in the prolonged presence of M3G in plasma.
Negative_regulation (loss) of Mrp2 in plasma
2) Confidence 0.57 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485564 Disease Relevance 0 Pain Relevance 0.25
We show here that loss of multidrug resistance protein 2 (MRP2/ABCC2) and breast cancer resistance protein (BCRP/ABCG2) in mice results in highly increased plasma levels of diclofenac acyl glucuronide, after both oral and intravenous administration.
Negative_regulation (loss) of MRP2 in plasma associated with breast cancer and diclofenac
3) Confidence 0.43 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.47 Pain Relevance 0.60
In fact, grapefruit juice has also shown inhibition of multidrug resistant protein 2 (MRP2), an efflux protein closely related to Pgp in terms of its expression and function [26].
Negative_regulation (inhibition) of multidrug resistant protein 2
4) Confidence 0.01 Published 2007 Journal Nutr J Section Body Doc Link PMC2147024 Disease Relevance 0 Pain Relevance 0.20

General Comments

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