INT143809

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.25

transport (Abcc2) ATPase activity (Abcc2) transmembrane transport (Abcc2)

Anatomy Link Frequency plasma 3 Abcc2 (Mus musculus) H2-M3 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 3 88.44

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Combined loss of Mrp2 and Mrp3 leads to a substantial accumulation of M3G in the liver, from which it is transported across the sinusoidal membrane at a low rate, resulting in the prolonged presence of M3G in plasma.

Negative_regulation (loss) of Mrp2 in plasma Positive_regulation (leads) of Positive_regulation (accumulation) of M3G in plasma

1) Confidence 0.04 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485564 Disease Relevance 0 Pain Relevance 0.25

General Comments

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