INT143838

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.86
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pitx2) DNA binding (Pitx2) transcription factor binding (Pitx2)
cytoplasm (Pitx2)
Pitx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 85.44 High High
Inflammation 45 50.00 Quite Low
medulla 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 73 98.28 Very High Very High Very High
Hydrocephalus 2 96.88 Very High Very High Very High
Deafness 3 96.32 Very High Very High Very High
Overactive Bladder 61 96.04 Very High Very High Very High
Intellectual Impairment 3 89.20 High High
Growth Problems 1 88.24 High High
Convulsion 4 87.04 High High
Arthralgia 1 85.68 High High
Congenital Anomalies 23 85.40 High High
Eye Malformation 2 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Satb2, Pitx2, Trps1, Tcof1, Cited2), expression changes in the same genes in Nipbl+/?
Gene_expression (expression) of Pitx2
1) Confidence 0.53 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.47 Pain Relevance 0
In addition to Pax-3, other TREs such as: PITX2, CDP, and c-Myb were also found over-represented (figure 5).
Gene_expression (represented) of PITX2
2) Confidence 0.33 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.48 Pain Relevance 0
Absence of PITX2, BARX1, and FOXC1 mutations in De Hauwere syndrome (Axenfeld-Rieger anomaly, hydrocephaly, hearing loss): a 25-year follow up.
Neg (Absence) Gene_expression (Absence) of PITX2 associated with deafness, syndrome and hydrocephalus
3) Confidence 0.27 Published 2007 Journal Am. J. Med. Genet. A Section Title Doc Link 17486624 Disease Relevance 0.91 Pain Relevance 0.09

General Comments

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