INT14384

Context Info Confidence 0.60 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 3.03 Pain Relevance 2.22

cytosol (Prf1) endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) molecular_function (Prf1)

Anatomy Link Frequency surface epithelium 1 lymph node 1 nerves 1 corpus callosum 1 MNC 1 Prf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuritis 18 99.96 cytokine 10 98.92 noradrenaline 1 97.72 Inflammation 5 93.04 Demyelination 2 92.36 Peripheral nervous system 7 91.52 ketamine 4 90.08 tetrodotoxin 1 85.52 guanethidine 1 83.84 anesthesia 5 78.16

Disease Link Frequency Relevance Heat Experimental Autoimmune Neuritis 18 99.96 Convalescence 2 98.28 Disease 10 98.12 Pancreatitis 80 97.64 Syndrome 2 94.12 INFLAMMATION 5 93.04 Demyelinating Disease 2 92.36 Immunization 2 91.42 Apoptosis 20 84.56 Injury 113 63.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that P1 and P2 receptors are present in rat duodenum, but their activation is not responsible for the inhibitor effects due to the NANC nerves.

Gene_expression (present) of P1 in nerves

1) Confidence 0.60 Published 1990 Journal Arch. Int. Physiol. Biochim. Section Abstract Doc Link 1692694 Disease Relevance 0 Pain Relevance 0.18

Final n's for each group were: sham P1 (n = 5), sham P3 (n = 6), sham P5 (n = 5), (total sham= 16); P1 lesion (n = 13); P3 lesion (n = 17); P5 lesion (n = 17).

Gene_expression (lesion) of P1

2) Confidence 0.55 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.05 Pain Relevance 0.10

Final n's for each group were: sham P1 (n = 5), sham P3 (n = 6), sham P5 (n = 5), (total sham= 16); P1 lesion (n = 13); P3 lesion (n = 17); P5 lesion (n = 17).

Gene_expression (lesion) of P1

3) Confidence 0.55 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.05 Pain Relevance 0.10

A univariate ANOVA was computed for corpus callosum volume, using Age at Treatment (3 levels; P1, 3, 5) and Treatment (2 levels; Sham, Lesion) as fixed factors (Figure 2).

Gene_expression (using) of P1 in corpus callosum

4) Confidence 0.55 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2204005 Disease Relevance 0.06 Pain Relevance 0

In the anaesthetised subjects, only the P1 potential was present.

Gene_expression (present) of P1

5) Confidence 0.53 Published 1995 Journal J. Neurosci. Methods Section Abstract Doc Link 8531489 Disease Relevance 0 Pain Relevance 0

The parameters observed were F-VEP latency LP1 (P1 wave response time, ms) and amplitude AP1-N2 (delta between P1 wave trough and N2 wave peak, ?

Gene_expression (trough) of P1

6) Confidence 0.12 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013062 Disease Relevance 0.23 Pain Relevance 0.08

Experimental allergic neuritis: cytolysin mRNA expression is upregulated in lymph node cells during convalescence.

Gene_expression (expression) of cytolysin mRNA in lymph node associated with convalescence, experimental autoimmune neuritis and neuritis

7) Confidence 0.04 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9307234 Disease Relevance 1.02 Pain Relevance 0.92

Three patterns of cytokine mRNA expressing MNC in relation to clinical EAN could be distinguished: (i) IL-1beta mRNA expressing cells peaked already on day 3 post immunization (p.i.), and BPM- and P2-reactive TNF-alpha, and BPM-reactive IL-6 mRNA expressing cells were also detected already on day 7 p.i., i.e., before onset of clinical EAN; (ii) BPM- and P2-reactive TNF-alpha peaked together with P2-reactive TNF-beta, IL-6 and IL-12 mRNA expressing cells at height of clinical EAN, consistent with a disease-promoting role for these four cytokines; (iii) high levels of BPM- and P2-reactive IL-10 and cytolysin mRNA expressing cells were observed only during recovery (day 28 p.i.), consistent with a disease down-regulating role of IL-10 and cytolysin.

Gene_expression (expressing) of cytolysin mRNA in MNC associated with immunization, disease, neuritis and cytokine

8) Confidence 0.03 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9307234 Disease Relevance 1.00 Pain Relevance 0.85

Contrary to occludin and claudin-1, the pore-forming TJ protein, claudin-2 [7], was only scarcely detectable in crypts of sham-operated animals, whereas rats from the AP group showed intense staining of claudin-2 both in crypt and surface epithelium (fig 3).

Gene_expression (detectable) of pore-forming in surface epithelium associated with pancreatitis

9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.62 Pain Relevance 0

General Comments

This test has worked.