INT143841

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Context Info
Confidence 0.17
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 5.46
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
neural 3
neurons 2
platelet 2
ligament 1
pituitary 1
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 65 99.04 Very High Very High Very High
Acupuncture 3 98.40 Very High Very High Very High
nociceptor 33 97.52 Very High Very High Very High
Osteoarthritis 92 96.96 Very High Very High Very High
antagonist 120 95.36 Very High Very High Very High
Nerve growth factor 93 94.56 High High
withdrawal 24 93.68 High High
Glutamate 42 93.52 High High
Dopamine 39 92.56 High High
Inflammatory response 25 91.56 High High
Disease Link Frequency Relevance Heat
Disease 29 99.88 Very High Very High Very High
Nervous System Injury 9 99.72 Very High Very High Very High
Pituitary Cancer 34 99.38 Very High Very High Very High
Cancer 78 99.34 Very High Very High Very High
Injury 221 99.08 Very High Very High Very High
Pain 62 99.04 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 98.40 Very High Very High Very High
Hematoma 2 98.28 Very High Very High Very High
Osteoarthritis 101 96.96 Very High Very High Very High
Hypersensitivity 3 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of growth factors to stimulate chondrocyte development are on the horizon as new treatment modalities for degenerative disc disease, but increasing growth factor concentrations in the body may have adverse affects on vital organs.
Positive_regulation (increasing) of growth factor in body associated with disease
1) Confidence 0.17 Published 2007 Journal Biomed Sci Instrum Section Abstract Doc Link 17487112 Disease Relevance 0.44 Pain Relevance 0.09
According to Stener-Victorin et al [17], the bilateral electro acupuncture stimulation in the somatic segments of the ovaries' innervations results in an increase in neural growth factor levels in the ovaries, which in turn stimulates testosterone secretion.
Positive_regulation (increase) of neural growth factor in neural associated with acupuncture
2) Confidence 0.08 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1448196 Disease Relevance 0 Pain Relevance 0.24
The increase in testosterone secretion in response to an increase in neural growth factor levels has also been shown by Lara's group [18].
Positive_regulation (increase) of neural growth factor in neural
3) Confidence 0.08 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1448196 Disease Relevance 0 Pain Relevance 0.17
Since perforating the peritoneum affected the same somatic segments used by Stener-Victorin et. al. [17], we presume that bilateral and left side surgical procedures resulted in an increase of neural growth factor concentrations at the ovarian level, which in turn induced the increase in testosterone secretion.
Positive_regulation (increase) of neural growth factor in neural
4) Confidence 0.06 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1448196 Disease Relevance 0 Pain Relevance 0.09
If substantiated, then rapid removal of IGF-1 from the brain reported herein may be the reason for the lesser effectiveness of this growth factor.


Positive_regulation (effectiveness) of growth factor in brain
5) Confidence 0.04 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.10 Pain Relevance 0.15
Quantitative automated microscopy (QuAM) elucidates growth factor specific signalling in pain sensitization

Background

Positive_regulation (elucidates) of growth factor associated with pain
6) Confidence 0.03 Published 2010 Journal Mol Pain Section Title Doc Link PMC3023724 Disease Relevance 0.17 Pain Relevance 0.29
On one hand GDNF is an essential growth factor for the survival and functional maintenance of a subgroup of nociceptors during development and after insult [16,17].
Positive_regulation (essential) of growth factor in nociceptors associated with nociceptor
7) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.50 Pain Relevance 0.37
Functional subsets of neurons can be defined by growth factor induced increases of pErk1/2 intensities on a single cell level
Positive_regulation (increases) of growth factor in neurons
8) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.07 Pain Relevance 0.07
Furthermore, GDNF, another growth factor whose expression is also upregulated after nerve injury can activate ERK in cultured DRG neurons [15].
Positive_regulation (upregulated) of growth factor in neurons associated with nervous system injury
9) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.34 Pain Relevance 0.13
It therefore appears that pituitary adenomas may be growing faster by both increased growth factor stimulation and the decreased availability of endogenous antiproliferative protection mechanisms.
Positive_regulation (increased) of growth factor in pituitary associated with pituitary cancer
10) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.51 Pain Relevance 0
, proliferin, platelet-derived growth factor, IL-8, TGF-?
Positive_regulation (derived) of growth factor in platelet
11) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0
Insulin growth factor (IGF)-I-stimulated PRL release (but not IGF-I-inhibition of GH release) could also be blunted by anti-VIP antibody (360).
Positive_regulation (blunted) of growth factor
12) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.08 Pain Relevance 0.27
Significant upregulation of several growth factor receptor genes (GFRa1, Ret, Lifr) also occurred only during the initial period examined.
Positive_regulation (upregulation) of growth factor
13) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2894843 Disease Relevance 0.68 Pain Relevance 0.22
In the future, it appears hopeful that a new generation of growth factor therapy will follow becaplermin for the treatment these chronic wounds.



Positive_regulation (generation) of growth factor associated with injury
14) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 0.63 Pain Relevance 0
We suggest the need for similar investigations to those that have been performed in ligament, where the profile of growth factor induction and expression during injury and repair have been more extensively investigated [88,89].


Positive_regulation (induction) of growth factor in ligament associated with injury
15) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128932 Disease Relevance 0.31 Pain Relevance 0.03
Activation of PI 3-kinase has been shown to be necessary and sufficient for growth factor–induced increase in Akt phosphorylation (38).
Positive_regulation (increase) of growth factor
16) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
The fibrin network within the hematoma traps platelets that, in turn, release various bioactive factors, including platelet derived growth factor (PDGF) and transforming growth factor (TGF)-?
Positive_regulation (derived) of growth factor in platelets associated with hematoma and tumor necrosis factor receptor-associated periodic syndrome
17) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.69 Pain Relevance 0.06
FGF8 was originally isolated from the conditioned medium of an androgen-dependent mouse mammary tumor cell line (SC-3) as an androgen-induced growth factor, and was later classified as a member of the FGF family based on structural similarity [9].
Positive_regulation (induced) of growth factor associated with cancer
18) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.46 Pain Relevance 0.29
Fibroblast growth factor 8 (FGF8) is isolated as an androgen-induced growth factor, and has recently been shown to contribute to limb morphogenesis.
Positive_regulation (induced) of growth factor in limb
19) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575604 Disease Relevance 0.42 Pain Relevance 0.21

General Comments

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