INT143846

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.40
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INPP5K) endoplasmic reticulum (INPP5K) plasma membrane (INPP5K)
nucleus (INPP5K) cytoplasm (INPP5K)
Anatomy Link Frequency
respiratory 2
FAE 1
domes 1
INPP5K (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 12 98.60 Very High Very High Very High
headache 9 73.16 Quite High
Inflammation 61 47.20 Quite Low
Spinal cord 12 46.20 Quite Low
Inflammatory marker 3 43.92 Quite Low
Pain 39 38.28 Quite Low
Analgesic 3 32.96 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
Piles 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 123 100.00 Very High Very High Very High
Inflammatory Bowel Disease 96 99.70 Very High Very High Very High
Respiratory Failure 15 99.64 Very High Very High Very High
Cough 3 98.84 Very High Very High Very High
Nicotine Addiction 3 98.06 Very High Very High Very High
Polio 90 97.72 Very High Very High Very High
Infection 15 84.04 Quite High
Disease 42 77.52 Quite High
Frailty 29 76.92 Quite High
Ileitis 16 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 8 UC patients, as in healthy controls, the PPs’ domes were slightly elevated, covered with the regular FAE lining, and surrounded by dense and bulky villi; however, in 10 UC patients, the PPs’ domes were irregular, and the surrounding villi were sparse and atrophic.
Positive_regulation (elevated) of PPs in FAE associated with inflammatory bowel disease
1) Confidence 0.40 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2831089 Disease Relevance 0.82 Pain Relevance 0
Prior to initial treatment, in 8 of the 18 UC patients, the PPs’ domes were slightly elevated, covered with the regular FAE lining, and surrounded by dense and bulky villi, as previously observed in healthy controls [6].
Positive_regulation (elevated) of PPs in domes associated with inflammatory bowel disease
2) Confidence 0.40 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.75 Pain Relevance 0
PPS patients with a tracheostoma and mechanical home ventilation are reported to have good quality of life despite severe physical disability.62 In line with other muscle training in PPS, respiratory muscle training is useful, including for patients already using an intermittent noninvasive respiratory aid.63 General measures like stopping smoking, mobilization of secretions, and cough assistance are beneficial, and should be followed in all cases with PPS-related respiratory insufficiency.45,60
Positive_regulation (cases) of PPS in respiratory associated with nicotine addiction, syndrome, respiratory failure and cough
3) Confidence 0.39 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.50 Pain Relevance 0.06
PPS patients with a tracheostoma and mechanical home ventilation are reported to have good quality of life despite severe physical disability.62 In line with other muscle training in PPS, respiratory muscle training is useful, including for patients already using an intermittent noninvasive respiratory aid.63 General measures like stopping smoking, mobilization of secretions, and cough assistance are beneficial, and should be followed in all cases with PPS-related respiratory insufficiency.45,60
Positive_regulation (useful) of PPS in respiratory associated with nicotine addiction, syndrome, respiratory failure and cough
4) Confidence 0.39 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.60 Pain Relevance 0.07
The symptoms were common to different polio populations all over the world, and as the reports were systematically recorded, the term “post-polio syndrome” (PPS) were coined in the 1980s, describing this new, late manifestation of polio after several years with stable function following initial recovery.2 Public awareness of this topic seems to be increasing,3 and the term PPS is now widely accepted.
Positive_regulation (increasing) of PPS associated with polio and syndrome
5) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.72 Pain Relevance 0
Similar levels of 8 bipyrimidine photoproducts including cyclobutane pyrimidine dimers (CPDs) (T<>T, T<>C, C<>T), (6-4) photoproducts ((6-4)PPs) (TT-(6-4)PPs, TC-(6-4)PPs) and their Dewar valence isomers together with 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) were found to be generated in both non-transfected and HaCaT-MC1R cells after UVB exposure.
Positive_regulation (generated) of PPs associated with melanocortin 1 receptor
6) Confidence 0.18 Published 2007 Journal Photochem. Photobiol. Sci. Section Abstract Doc Link 17487313 Disease Relevance 0 Pain Relevance 0.52
Similar levels of 8 bipyrimidine photoproducts including cyclobutane pyrimidine dimers (CPDs) (T<>T, T<>C, C<>T), (6-4) photoproducts ((6-4)PPs) (TT-(6-4)PPs, TC-(6-4)PPs) and their Dewar valence isomers together with 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) were found to be generated in both non-transfected and HaCaT-MC1R cells after UVB exposure.
Positive_regulation (generated) of PPs associated with melanocortin 1 receptor
7) Confidence 0.18 Published 2007 Journal Photochem. Photobiol. Sci. Section Abstract Doc Link 17487313 Disease Relevance 0 Pain Relevance 0.52

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