INT143850

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 19
Total Number 25
Disease Relevance 9.52
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100a1) cytoplasm (S100a1)
Anatomy Link Frequency
neutrophils 3
macrophages 2
aggregate cell 1
dendritic cells 1
cleft 1
S100a1 (Mus musculus)
S100a1 - S100A (6)
Pain Link Frequency Relevance Heat
Inflammation 808 99.56 Very High Very High Very High
cytokine 228 98.64 Very High Very High Very High
Pain 12 91.72 High High
Arthritis 20 89.64 High High
rheumatoid arthritis 10 80.12 Quite High
pain flank 1 73.68 Quite High
corticosteroid 12 68.48 Quite High
Inflammatory stimuli 10 64.48 Quite High
imagery 15 58.88 Quite High
Sciatic nerve 1 36.08 Quite Low
Disease Link Frequency Relevance Heat
Cancer 416 99.86 Very High Very High Very High
INFLAMMATION 842 99.56 Very High Very High Very High
Hyperplasia 35 98.36 Very High Very High Very High
Langerhans-cell Histiocytosis 6 98.32 Very High Very High Very High
Adenoid Cystic Carcinoma 3 98.08 Very High Very High Very High
Rhinitis 1 96.04 Very High Very High Very High
Wound Healing 16 95.48 Very High Very High Very High
Diabetes Insipidus 1 93.60 High High
Papular Skin Disease 1 93.36 High High
Stress 322 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up</span>regulation of S100A gene expression in corneas upon CorNV induction
Gene_expression (expression) of S100A gene (S100A) in corneas
1) Confidence 0.73 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.09 Pain Relevance 0
The RT-QPCR assay of S100A gene expression in the S-CorNV model revealed that the changes of all S100A genes manifested in a similar time-dependent manner, peaking around day 5 for all genes (Table 3).
Gene_expression (expression) of S100A gene (S100A)
2) Confidence 0.73 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.07 Pain Relevance 0
The dimers of interest in studies concerning cerebral events are those containing S100B (S100BB and S100A1B).
Gene_expression (containing) of S100A
3) Confidence 0.65 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.35 Pain Relevance 0
This implies that neutrophils are the main sources of S100A and other inflammatory molecules in S-CorNV.


Gene_expression (sources) of S100A (S100A) in neutrophils associated with inflammation
4) Confidence 0.64 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.49 Pain Relevance 0.13
Apart from the S100A proteins, representative pro-inflammatory cytokines (IL-1?
Gene_expression (proteins) of S100A (S100A) associated with inflammation and cytokine
5) Confidence 0.63 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.19 Pain Relevance 0.15
S100A proteins are reportedly produced mainly by macrophages and neutrophils, the two main cell types that infiltrated the corneas in CorNV models [3-5].
Gene_expression (produced) of S100A (S100A) in macrophages
6) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.15 Pain Relevance 0.08
We also considered the possibility that some wild-type TSCs might survive the transplantation to B6.EGFP mice and express S100 but not EGFP.
Neg (not) Gene_expression (express) of S100
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.13 Pain Relevance 0
S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].
Gene_expression (expressed) of S100 in macrophages
8) Confidence 0.34 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0
An iliac crest bone biopsy showed an eosinophil-rich infiltrate admixed with histiocytoid cells with reniform nuclei, which expressed S100 and CD1a, consistent with a diagnosis of LCH.
Gene_expression (expressed) of S100 in crest associated with langerhans-cell histiocytosis
9) Confidence 0.34 Published 2008 Journal J. Cutan. Pathol. Section Abstract Doc Link 18840155 Disease Relevance 1.04 Pain Relevance 0.09
They include the High Mobility Group family proteins including the prototypic HMGB1/amphoterin, members of the S100/calgranulin protein family, matrix proteins such as Collagen I and IV, A?
Gene_expression (members) of S100
10) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.02 Pain Relevance 0.11
S100 proteins have wildly varying expression patterns (Table 3).
Gene_expression (expression) of S100
11) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.19 Pain Relevance 0
Possible ligands of RAGE: S100A1, S100A8/9
Gene_expression (/) of S100A1
12) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.06 Pain Relevance 0
They include the High Mobility Group family proteins including the prototypic HMGB1/amphoterin, members of the S100/calgranulin protein family, matrix proteins such as Collagen I and IV, A?
Gene_expression (/) of S100
13) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.02 Pain Relevance 0.11
S100A1 is present in the cytoplasm and nucleus – rat heart muscle cell line H9c2 is mostly nuclear, adult skeletal muscle mostly cytoplasmic.
Gene_expression (present) of S100A1 in heart muscle cell
14) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.08 Pain Relevance 0.03
There are several important questions that need to be addressed when examining proposed S100-RAGE interactions: Does this interaction occur in vivo in addition to in vitro?
Spec (examining) Gene_expression (examining) of S100
15) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.98 Pain Relevance 0.29
S100A proteins are reportedly produced mainly by macrophages and neutrophils, the two main cell types that infiltrated the corneas in CorNV models [3-5].
Gene_expression (produced) of S100A (S100A) in neutrophils
16) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.15 Pain Relevance 0.08
Immunohistochemically, the tumor cells express low-molecular-weight keratins, carcinoembryonic antigen, lysozyme, alpha1-antichymotrypsin, S100, and type IV collagen.
Gene_expression (express) of S100 associated with cancer
17) Confidence 0.15 Published 2007 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17488169 Disease Relevance 1.19 Pain Relevance 0.08
S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].
Gene_expression (expressed) of S100 in dendritic cells
18) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0
S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].
Gene_expression (expressed) of S100 in neutrophils
19) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0
S100 proteins and calgranulins are expressed in various cell types, including neutrophils, macrophages, lymphocytes, and dendritic cells [2].
Gene_expression (expressed) of S100 in lymphocytes
20) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.25 Pain Relevance 0

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