INT14388

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 3.10
Pain Relevance 5.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TACR1) cytoplasm (TACR1) signal transducer activity (TACR1)
Anatomy Link Frequency
ileum 1
blood 1
neurons 1
nerves 1
nucleus 1
TACR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 50 100.00 Very High Very High Very High
substance P 44 100.00 Very High Very High Very High
Calcitonin gene-related peptide 3 100.00 Very High Very High Very High
agonist 11 99.96 Very High Very High Very High
Lasting pain 3 99.60 Very High Very High Very High
Pain 8 99.30 Very High Very High Very High
Dorsal horn 2 99.26 Very High Very High Very High
Neurotransmitter 7 98.88 Very High Very High Very High
Anterior cingulate 1 98.76 Very High Very High Very High
IPN 2 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 9 99.60 Very High Very High Very High
Inflammatory Pain 2 98.52 Very High Very High Very High
Heart Rate Under Development 3 98.04 Very High Very High Very High
Hypertension 2 97.40 Very High Very High Very High
Celiac Disease 3 95.56 Very High Very High Very High
Pathologic Processes 1 95.44 Very High Very High Very High
INFLAMMATION 7 93.28 High High
Vomiting 46 91.92 High High
Anxiety Disorder 3 91.48 High High
Urological Neuroanatomy 1 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the central NK1 receptor system is altered in human chronic pain.
Regulation (altered) of NK1 receptor associated with lasting pain
1) Confidence 0.45 Published 2010 Journal Pain Section Abstract Doc Link 20137858 Disease Relevance 0.65 Pain Relevance 0.66
It activates signal transduction cascades by acting on the neurokinin-1 receptor (NK(1)-R).
Regulation (acting) of neurokinin-1 receptor
2) Confidence 0.16 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17655927 Disease Relevance 0.17 Pain Relevance 0.38
Tachykinins exert a potent contractile effect, independently of cholinergic nerves, via NK-1 and NK-2 receptors.
Regulation (effect) of NK-1 in nerves
3) Confidence 0.15 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1692976 Disease Relevance 0 Pain Relevance 0.40
We addressed this by assessing the effects of the neurokinin-1 receptor antagonist GR205171A and ibuprofen on Fos expression following stimulation of the inflamed pulp and comparing this with known analgesic efficacy.
Regulation (effects) of neurokinin-1 receptor associated with analgesic and antagonist
4) Confidence 0.11 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17897851 Disease Relevance 0.26 Pain Relevance 0.46
The effects of ibuprofen and the neurokinin-1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation.
Regulation (effects) of neurokinin-1 receptor in nucleus associated with antagonist
5) Confidence 0.11 Published 2008 Journal Eur J Pain Section Title Doc Link 17897851 Disease Relevance 0.24 Pain Relevance 0.41
The effects of systemically-administered human alpha calcitonin gene-related peptide (h.alpha CGRP), substance P and the selective neurokinin receptor agonists, GR73632 (NK1) and GR64349 (NK2) on cerebral blood flow (CBF) were studied in anaesthetized guinea-pigs using a laser-Doppler flowmeter. h.alpha CGRP (0.1 and 0.3 nmol/kg), substance P (0.03-1.0 nmol/kg), GR73632 (0.03-0.3 nmol/kg) and GR64349 (0.3 nmol/kg) each, following intra-carotid artery injection, reduced transiently (< 5 min) blood pressure and CBF.
Regulation (effects) of neurokinin receptor in blood associated with agonist, substance p and calcitonin gene-related peptide
6) Confidence 0.11 Published 1993 Journal Neuropeptides Section Abstract Doc Link 7688875 Disease Relevance 0 Pain Relevance 0.27
Clinical and in vitro studies have demonstrated that the major enzymes involved in the metabolism of the NK-1 receptor antagonist casopitant are from the CYP3A family and that casopitant (and a major circulating metabolite) can result in weak to moderate inhibition of CYP3A.
Regulation (metabolism) of NK-1 receptor associated with antagonist
7) Confidence 0.11 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2726912 Disease Relevance 0.45 Pain Relevance 0.48
In the present studies, therefore, we examined a range of tachykinin receptor agonists for a capacity to induce contractions of the isolated ileum.
Spec (examined) Regulation (range) of tachykinin receptor in ileum associated with agonist
8) Confidence 0.10 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18582934 Disease Relevance 0.09 Pain Relevance 0.33
Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists.
Regulation (modulation) of tachykinin receptor associated with antagonist
9) Confidence 0.09 Published 2001 Journal J. Med. Chem. Section Title Doc Link 11356103 Disease Relevance 0 Pain Relevance 0.20
Further, Li et al. [19] have reported that there is no effect of a similar NK-1 receptor antagonist, aprepitant, on the PK and cardiac safety profile of hydrodolasetron in CYP2D6 EMs or PMs.
Neg (no) Regulation (effect) of NK-1 receptor associated with antagonist
10) Confidence 0.04 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2726911 Disease Relevance 0.09 Pain Relevance 0.15
Glutamate is an excitatory neurotransmitter in the dorsal horn, and its effects are enhanced by SP acting on neurokinin 1 receptors (NK1Rs).
Regulation (acting) of NK1Rs in dorsal horn associated with neurotransmitter, glutamate, dorsal horn and substance p
11) Confidence 0.02 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9334388 Disease Relevance 0.09 Pain Relevance 0.69
The mammalian NK1 tachykinin receptor antagonist CP-96,345 did not affect the responses to tSP or tNKA.
Neg (not) Regulation (affect) of mammalian NK1 tachykinin receptor associated with antagonist
12) Confidence 0.01 Published 1996 Journal Peptides Section Abstract Doc Link 8822508 Disease Relevance 0.51 Pain Relevance 0.16
It is generally believed that SP regulates pain transmission and sensitization by acting on neurokinin-1 receptor (NK-1), which is expressed in postsynaptic dorsal horn neurons.
Regulation (acting) of neurokinin-1 receptor in neurons associated with pain, dorsal horn neuron and substance p
13) Confidence 0.01 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978048 Disease Relevance 0.55 Pain Relevance 0.99

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