INT143912

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.51
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) cytoplasm (Src)
cell proliferation (Src) cell adhesion (Src) nucleus (Src)
Anatomy Link Frequency
neurons 1
Src (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 7 98.96 Very High Very High Very High
Inflammatory response 7 90.64 High High
cytokine 25 87.00 High High
antagonist 3 85.96 High High
Root ganglion neuron 2 75.00 Quite High
mu opioid receptor 1 75.00 Quite High
Potency 1 71.60 Quite High
Enkephalin 1 70.20 Quite High
Morphine 2 68.32 Quite High
Inflammation 40 50.00 Quite Low
Disease Link Frequency Relevance Heat
Genetic Translocation 1 100.00 Very High Very High Very High
Sarcoma 3 98.96 Very High Very High Very High
Lymphatic System Cancer 2 98.96 Very High Very High Very High
Myelodysplastic Syndromes 62 98.72 Very High Very High Very High
Cancer 160 92.44 High High
Reticulocytosis 5 90.44 High High
INFLAMMATION 47 90.24 High High
Erythrocytosis 35 89.64 High High
Adhesions 5 79.44 Quite High
Apoptosis 11 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of the nonreceptor tyrosine kinase c-Src appeared disrupted in beta arr2-/- neurons, and there was reduced activation of c-Src by DAMGO.
Localization (localization) of Src in neurons
1) Confidence 0.48 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17494695 Disease Relevance 0.14 Pain Relevance 0.59
These studies suggest that other Src family kinases are not compensating for deficiency of Lyn, Hck, and Fgr, and argue that therapy directed at Src kinases will be ineffective in PV patients.
Localization (directed) of Src associated with myelodysplastic syndromes
2) Confidence 0.41 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.95 Pain Relevance 0
Meanwhile, cellular transformation by the cytoplasmic tyrosine kinase c-src [23] or chromosomal translocation involving the anaplastic lymphoma kinase Alk is also dependent on Stat3 [24,25].
Localization (translocation) of src associated with lymphatic system cancer and genetic translocation
3) Confidence 0.17 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.88 Pain Relevance 0.19
CSK c-src tyrosine kinase
Localization (kinase) of src
4) Confidence 0.04 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.54 Pain Relevance 0

General Comments

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