INT143945

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.39
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (EWSR1) plasma membrane (EWSR1) nucleus (EWSR1)
intracellular (EWSR1) cytoplasm (EWSR1)
Anatomy Link Frequency
band 1
EWSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 61.52 Quite High
imagery 4 10.28 Low Low
vincristine 1 5.00 Very Low Very Low Very Low
neuralgia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 176 98.86 Very High Very High Very High
Bone Cancer 44 97.04 Very High Very High Very High
Clear Cell Sarcoma 84 94.48 High High
Death 2 93.20 High High
Sarcoma 20 86.80 High High
Metastasis 7 85.20 High High
Disease 6 80.32 Quite High
Necrosis 4 79.80 Quite High
Rhinitis 4 75.80 Quite High
Primitive Neuroectodermal Tumors 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm the suspected EWS-FEV translocation, a dual-color break-apart probe for FEV on chromosome band 2q36 [6] was applied to the cultured specimen.
Localization (translocation) of EWS-FEV in band
1) Confidence 0.78 Published 2010 Journal Mol Cytogenet Section Body Doc Link PMC2908072 Disease Relevance 0.38 Pain Relevance 0
Multi-color karyotyping identified the presence of a t(2;22)(q34;q12) that was initially expected to represent a variant EWSR1-FEV translocation.
Localization (translocation) of EWSR1
2) Confidence 0.68 Published 2010 Journal Mol Cytogenet Section Abstract Doc Link PMC2908072 Disease Relevance 0.60 Pain Relevance 0
Small blue round cell tumor of the interosseous membrane bearing a t(2;22)(q34;q12)/EWS-CREB1 translocation: a case report

Background

Localization (translocation) of EWS associated with cancer
3) Confidence 0.68 Published 2010 Journal Mol Cytogenet Section Title Doc Link PMC2908072 Disease Relevance 0.61 Pain Relevance 0
It was another 20 years before chemotherapy was used, and another 20+ years before the EWS-FLI1 translocation gave insight into its biology, and yet another 20 years before significant improvements in chemotherapy were realized.
Localization (translocation) of EWS-FLI1
4) Confidence 0.44 Published 2011 Journal Sarcoma Section Body Doc Link PMC2995899 Disease Relevance 1.03 Pain Relevance 0
Nine cases with material for reverse transcription-polymerase chain reaction revealed 1 positive type 2 translocation (EWS exon 7 to Fli-1 exon 5), 4 negative, and 4 "unable to amplify."
Localization (translocation) of EWS exon 7
5) Confidence 0.01 Published 2007 Journal Ann Diagn Pathol Section Abstract Doc Link 17498589 Disease Relevance 0.77 Pain Relevance 0.06

General Comments

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