INT143950

Context Info Confidence 0.45 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.46 Pain Relevance 0.23

nucleoplasm (NFKB1, RELA) cytoplasm (NFKB1, RELA) cytosol (NFKB1, RELA) nucleus (NFKB1, RELA) mitochondrion (NFKB1) aging (RELA)

NFKB1 (Homo sapiens) RELA (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 91.12 Osteoarthritis 1 78.48 Arthritis 1 72.24 Pain 1 70.84

Disease Link Frequency Relevance Heat Arthritis 2 91.60 Fibrosarcoma 2 75.80 INFLAMMATION 1 71.52 Arthralgia 1 70.84 Osteoarthritis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.

Negative_regulation (regulation) of NF-kappaB Positive_regulation (resulted) of Gene_expression (production) of p65

1) Confidence 0.45 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.46 Pain Relevance 0.23

General Comments

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