INT143952

Context Info Confidence 0.53 First Reported 2004 Last Reported 2010 Negated 2 Speculated 4 Reported most in Body Documents 14 Total Number 18 Disease Relevance 10.16 Pain Relevance 2.73

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9) proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)

Anatomy Link Frequency MDA-MB-231 2 PGE2 2 monocyte 2 multinucleated giant cells 2 plaque 2 MMP9 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 214 100.00 cINOD 27 100.00 Osteoarthritis 3 99.68 Inflammation 116 98.72 COX2 5 98.32 cva 10 86.08 Inflammatory stimuli 1 85.20 cytokine 22 78.32 Arthritis 6 67.72 Pain 14 66.32

Disease Link Frequency Relevance Heat INFLAMMATION 133 100.00 Knee Osteoarthritis 1 99.88 Prostate Cancer 167 99.84 Giant Cell Tumors 68 99.84 Cancer 232 99.52 Arthritis 7 98.08 Rupture 19 97.76 Hypersensitivity 5 97.24 Aneurism 11 96.36 Necrosis 5 95.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The result indicates that the PI3K pathway has a central role in regulation of monocyte MMP-9 production following stimulation with AA.

Regulation (regulation) of Gene_expression (production) of monocyte MMP-9 in monocyte

1) Confidence 0.53 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.09 Pain Relevance 0

B is also involved in MMP-9 expression [22,23].

Regulation (involved) of Gene_expression (expression) of MMP-9

2) Confidence 0.52 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1413525 Disease Relevance 0.88 Pain Relevance 0.32

Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.

Regulation (affected) of Gene_expression (expressions) of MMP-9

3) Confidence 0.38 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.45 Pain Relevance 0.22

Similarly, flurbiprofen was also demonstrated to inhibit ERK activation and to down-regulate MMP-9 expression.

Regulation (regulate) of Gene_expression (expression) of MMP-9

4) Confidence 0.38 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.40 Pain Relevance 0.29

OBJECTIVES: The purpose of this study was to examine the ex vivo effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of urokinase-type plasminogen activator (u-PA), PA inhibitor-1 (PAI-1) and gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] in the early knee osteoarthritis (OA) of humans.

Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of MMP-9 in knee associated with inflammation, knee osteoarthritis, metalloproteinase, cinod and osteoarthritis

5) Confidence 0.33 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 17996201 Disease Relevance 0.35 Pain Relevance 0.47

This study shows that of the PUFA studied, AA alone influences the expression of MMP-9, which might have implications in MMP-9 induced plaque rupture.

Regulation (influences) of Gene_expression (expression) of MMP-9 in plaque associated with rupture

6) Confidence 0.27 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2667508 Disease Relevance 0.32 Pain Relevance 0.12

Wang et al. isolated the sulfated S. maindroni ink polysaccharide (SIP-SII) from cuttlefish Sepiella maindroni, and examined the effects of SIP-SII on the expression of matrix metalloproteinases MMP-2 and MMP-9 as well as tumor cell invasion and migration.

Spec (examined) Regulation (effects) of Gene_expression (expression) of MMP-9 associated with cancer and metalloproteinase

7) Confidence 0.24 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.35 Pain Relevance 0.10

We determined how these PUFAs influence MMP-9 expression and secretion by the human monocytic cell line (MonoMac 6) at baseline and after 24-hour exposure.

Spec (determined) Regulation (influence) of Gene_expression (expression) of MMP-9

8) Confidence 0.23 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2667508 Disease Relevance 0.36 Pain Relevance 0.18

This result further points to the involvement of PI3K signalling system in AA-induced MMP-9 production.

Regulation (involvement) of Gene_expression (production) of MMP-9

9) Confidence 0.23 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.16 Pain Relevance 0

No changes in the surface levels of MMP-9 also serve as a biotinylation control for surface labeling.

Neg (No) Regulation (changes) of Gene_expression (levels) of MMP-9

10) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.18 Pain Relevance 0

There are no changes in the surface levels of MMP-9 in PC3 cell lines, and only a single band of MMP-9 protein (85–90 kDa) was detected in all cells (Figure 2C).

Neg (no) Regulation (changes) of Gene_expression (levels) of MMP-9 in band

11) Confidence 0.18 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.06 Pain Relevance 0

This pathway controls synthesis of prostaglandin E2 (PGE2) and thus expression of MMP-9 (Miralles et al 1999).

Regulation (controls) of Gene_expression (expression) of MMP-9 in PGE2

12) Confidence 0.17 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.76 Pain Relevance 0.49

Determination of CSF and serum levels of MMP-9 and CxCL-13

Regulation (Determination) of Gene_expression (levels) of MMP-9 associated with metalloproteinase

13) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.24 Pain Relevance 0.28

As expression of MMP-9 gene is an outcome of NF?

Regulation (outcome) of Gene_expression (expression) of MMP-9 gene

14) Confidence 0.13 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 1.17 Pain Relevance 0.07

Currently, little is known about the role of PAR1 in prostate cancer progression and studies are underway to determine the effect of PAR1 stimulation on MMP-9 expression in prostate cancer cells.

Spec (determine) Regulation (effect) of Gene_expression (expression) of MMP-9 associated with metalloproteinase and prostate cancer

15) Confidence 0.08 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.25 Pain Relevance 0.05

An essential cell-cell interaction in the regulation of MMP-9 expression exists in GCT [16].

Regulation (regulation) of Gene_expression (expression) of MMP-9 in GCT associated with giant cell tumors

16) Confidence 0.04 Published 2005 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1253509 Disease Relevance 1.44 Pain Relevance 0.06

Studies suggest that TNF-alpha secreted by the multinucleated giant cells up-regulates MMP-9 expression in GCT stromal cells by the induction of certain transcription factors, which in turn enhanced the rate of transcription of MMP-9 gene.

Regulation (regulates) of Gene_expression (expression) of MMP-9 in multinucleated giant cells associated with giant cell tumors

17) Confidence 0.03 Published 2005 Journal BMC Ear Nose Throat Disord Section Body Doc Link PMC1253509 Disease Relevance 1.54 Pain Relevance 0.06

Expression of MMP-9 was 10–30 times higher on soft substrates for MDA-MB-231, but the effects of rigidity on MMP-9 expression observed for RWGT2 and MCF-7 cells were substantially smaller.

Regulation (effects) of Gene_expression (expression) of MMP-9 in MDA-MB-231

18) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.17 Pain Relevance 0.03

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