INT143953

Context Info Confidence 0.44 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.25 Pain Relevance 0.69

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2) proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)

Anatomy Link Frequency thyroid 2 MMP2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 57 100.00 Inflammation 3 95.84 Osteoarthritis 1 83.20 Arthritis 1 67.72 Pain 2 66.32 palliative 4 62.92 Glutamate 1 55.04 Sicca syndrome 1 5.00 imagery 1 5.00 Dysuria 1 5.00

Disease Link Frequency Relevance Heat Thyroid Neoplasm 161 99.48 Arthritis 2 96.32 Cancer 90 95.28 Disease 29 89.72 Carcinoma 25 89.60 Bladder Cancer 29 88.76 Renal Cancer 5 81.76 Fibrosarcoma 2 75.00 Aggression 2 71.20 INFLAMMATION 2 67.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

More recently, studies have demonstrated that differentiated thyroid cancer cell invasion in vivo is regulated through EGFR-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A (Yeh et al 2006).

Regulation (regulated) of Positive_regulation (activation) of gelatinase A in thyroid associated with thyroid neoplasm and metalloproteinase

1) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.92 Pain Relevance 0.24

Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].

Regulation (regulated) of Positive_regulation (Activated) of MMP2 associated with metalloproteinase

2) Confidence 0.42 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.89 Pain Relevance 0.23

Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.

Regulation (affected) of Positive_regulation (activation) of MMP-2

3) Confidence 0.37 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.44 Pain Relevance 0.22

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