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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.25
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
thyroid 2
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 57 100.00 Very High Very High Very High
Inflammation 3 95.84 Very High Very High Very High
Osteoarthritis 1 83.20 Quite High
Arthritis 1 67.72 Quite High
Pain 2 66.32 Quite High
palliative 4 62.92 Quite High
Glutamate 1 55.04 Quite High
Sicca syndrome 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Dysuria 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 161 99.48 Very High Very High Very High
Arthritis 2 96.32 Very High Very High Very High
Cancer 90 95.28 Very High Very High Very High
Disease 29 89.72 High High
Carcinoma 25 89.60 High High
Bladder Cancer 29 88.76 High High
Renal Cancer 5 81.76 Quite High
Fibrosarcoma 2 75.00 Quite High
Aggression 2 71.20 Quite High
INFLAMMATION 2 67.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, studies have demonstrated that differentiated thyroid cancer cell invasion in vivo is regulated through EGFR-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A (Yeh et al 2006).
Regulation (regulated) of Positive_regulation (activation) of gelatinase A in thyroid associated with thyroid neoplasm and metalloproteinase
1) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.92 Pain Relevance 0.24
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Regulation (regulated) of Positive_regulation (Activated) of MMP2 associated with metalloproteinase
2) Confidence 0.42 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.89 Pain Relevance 0.23
Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.
Regulation (affected) of Positive_regulation (activation) of MMP-2
3) Confidence 0.37 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.44 Pain Relevance 0.22

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