INT143955

Context Info Confidence 0.35 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.48 Pain Relevance 0.20

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1) cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)

NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 1 85.84 Inflammation 2 85.12 Pain 1 84.44 Osteoarthritis 1 48.08

Disease Link Frequency Relevance Heat Fibrosarcoma 2 89.40 Arthritis 2 85.84 INFLAMMATION 1 85.12 Arthralgia 1 84.44 Osteoarthritis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further, transfection of promoter genes of MMPs and their transcription factors clearly exhibited that inhibition of MMP-2 and MMP-9 was due to down-regulation of transcription factor, NF-kappaB.

Negative_regulation (down) of Negative_regulation (regulation) of NF-kappaB

1) Confidence 0.35 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.48 Pain Relevance 0.20

General Comments

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