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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.61
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 99.36 Very High Very High Very High
metalloproteinase 97 97.28 Very High Very High Very High
Inflammation 22 96.64 Very High Very High Very High
Osteoarthritis 2 84.00 Quite High
Angina 2 80.40 Quite High
Inflammatory response 1 71.32 Quite High
rheumatoid arthritis 63 70.72 Quite High
Inflammatory mediators 1 68.12 Quite High
Arthritis 6 67.72 Quite High
Pain 3 66.32 Quite High
Disease Link Frequency Relevance Heat
Arthritis 7 97.12 Very High Very High Very High
Prostate Cancer 40 96.12 Very High Very High Very High
Cancer 71 95.28 Very High Very High Very High
Disease 10 89.72 High High
Rupture 6 89.00 High High
Bladder Cancer 29 88.76 High High
INFLAMMATION 24 85.96 High High
Renal Cancer 4 81.76 Quite High
Cv General 3 Under Development 2 80.40 Quite High
Fibrosarcoma 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Regulation (regulated) of Positive_regulation (Activated) of MMP9 associated with metalloproteinase
1) Confidence 0.40 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.89 Pain Relevance 0.23
Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.
Regulation (affected) of Positive_regulation (activation) of MMP-9
2) Confidence 0.38 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.44 Pain Relevance 0.22
MMP-9 activity is controlled at different levels: transcriptional activation of the gene by cytokines and other factors, activation of the pro-enzyme by various enzymes like serine proteases and regulation by specific tissue inhibitors of the matrix metalloproteinases (TIMPs).
Regulation (controlled) of Positive_regulation (activation) of MMP-9 associated with metalloproteinase and cytokine
3) Confidence 0.27 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.92 Pain Relevance 0.50
In parallel, the effect of IgG fractions on MMP9 activation was monitored.
Regulation (effect) of Positive_regulation (activation) of MMP9
4) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.19 Pain Relevance 0.15
The various steps involved in the above mentioned signaling pathway and/or the molecules regulating the activation of MMP-9 are potential therapeutic target.

Regulation (regulating) of Positive_regulation (activation) of MMP-9
5) Confidence 0.20 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.17 Pain Relevance 0

General Comments

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