INT143956

Context Info Confidence 0.40 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.61 Pain Relevance 1.11

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9) proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)

MMP9 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 4 99.36 metalloproteinase 97 97.28 Inflammation 22 96.64 Osteoarthritis 2 84.00 Angina 2 80.40 Inflammatory response 1 71.32 rheumatoid arthritis 63 70.72 Inflammatory mediators 1 68.12 Arthritis 6 67.72 Pain 3 66.32

Disease Link Frequency Relevance Heat Arthritis 7 97.12 Prostate Cancer 40 96.12 Cancer 71 95.28 Disease 10 89.72 Rupture 6 89.00 Bladder Cancer 29 88.76 INFLAMMATION 24 85.96 Renal Cancer 4 81.76 Cv General 3 Under Development 2 80.40 Fibrosarcoma 3 75.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].

Regulation (regulated) of Positive_regulation (Activated) of MMP9 associated with metalloproteinase

1) Confidence 0.40 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.89 Pain Relevance 0.23

Moreover, down-regulation of NF-kappaB resulted in production of low levels of both NF-kappaB p50 and p65 proteins and directly affected activation process of MMP-2 and MMP-9 expressions.

Regulation (affected) of Positive_regulation (activation) of MMP-9

2) Confidence 0.38 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.44 Pain Relevance 0.22

MMP-9 activity is controlled at different levels: transcriptional activation of the gene by cytokines and other factors, activation of the pro-enzyme by various enzymes like serine proteases and regulation by specific tissue inhibitors of the matrix metalloproteinases (TIMPs).

Regulation (controlled) of Positive_regulation (activation) of MMP-9 associated with metalloproteinase and cytokine

3) Confidence 0.27 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.92 Pain Relevance 0.50

In parallel, the effect of IgG fractions on MMP9 activation was monitored.

Regulation (effect) of Positive_regulation (activation) of MMP9

4) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.19 Pain Relevance 0.15

The various steps involved in the above mentioned signaling pathway and/or the molecules regulating the activation of MMP-9 are potential therapeutic target.

Regulation (regulating) of Positive_regulation (activation) of MMP-9

5) Confidence 0.20 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.17 Pain Relevance 0

General Comments

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