INT143964

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 16
Disease Relevance 0.10
Pain Relevance 10.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
hippocampus 8
brain 2
caudate putamen 2
prefrontal 2
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 44 100.00 Very High Very High Very High
cocaine 42 99.98 Very High Very High Very High
Hippocampus 7 99.52 Very High Very High Very High
agonist 21 99.48 Very High Very High Very High
Morphine 18 99.44 Very High Very High Very High
Dopamine 840 99.40 Very High Very High Very High
tolerance 18 99.34 Very High Very High Very High
Kappa opioid receptor 14 99.32 Very High Very High Very High
Glutamate 217 99.08 Very High Very High Very High
Antinociceptive 14 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 2 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Thr in brain associated with analgesic, agonist, kappa opioid receptor and cocaine
1) Confidence 0.20 Published 2007 Journal Brain Res. Bull. Section Title Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.81
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of Thr in hippocampus associated with hippocampus and cocaine
2) Confidence 0.20 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Thr in hippocampus associated with hippocampus and cocaine
3) Confidence 0.20 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (increase) of in caudate putamen Phosphorylation (phosphorylation) of Thr in hippocampus associated with hippocampus and cocaine
4) Confidence 0.07 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (increase) of in prefrontal Phosphorylation (phosphorylation) of Thr in hippocampus associated with hippocampus and cocaine
5) Confidence 0.07 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (induces) of in prefrontal Phosphorylation (phosphorylation) of Thr in hippocampus associated with hippocampus and cocaine
6) Confidence 0.07 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (induces) of in caudate putamen Phosphorylation (phosphorylation) of Thr in hippocampus associated with hippocampus and cocaine
7) Confidence 0.07 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
The increase in Thr34 phosphorylation in its turn decreases PP1 (Figure 5C), and thus the ratio of PKAc to PP1 is greatly enhanced (Figure 5D) compared with dopamine alone.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Thr34 associated with dopamine
8) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.36
Repeated transient dopamine pulses, with temporal properties consistent with reinforcement learning trials (e.g., eight brief pulses at 20-s intervals) produces an accumulation of PKAc (Figure 5A, green dashed line), and significantly increases the phosphorylation of DARPP-32 at Thr34 (Figure 5B).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Thr34 associated with dopamine
9) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.31
For example, short pulses of calcium influx increase DARPP-32 phosphorylation at Thr34 compared with the decrease seen with prolonged stimulation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Thr34
10) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.24
Interestingly, our model suggests that the effect of transient calcium influx is very different from sustained calcium elevation and that short bursts of calcium influx actually increase DARPP-32 phosphorylation on Thr34 (Figure 4).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Thr34
11) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.25
The second set of simulations, using the validated model, showed that transient dopamine elevations increased the phosphorylation of Thr34 as expected, but transient calcium elevations also increased the phosphorylation of Thr34, contrary to what is believed.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Thr34 associated with dopamine
12) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Abstract Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.38
When transient calcium and dopamine stimuli were paired, PKA activation and Thr34 phosphorylation increased compared with dopamine alone.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Thr34 associated with dopamine
13) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Abstract Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.38
Recently, Nishi et al. used glutamate for brief stimulations (15 s) and did see an increase in phosphorylation at Thr34 [61].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Thr34 associated with glutamate
14) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.23
The present study indicates that Cdk5-mediated phosphorylation of DOR at Thr-161 plays a crucial role in the development of morphine tolerance and suggests the possibility of targeting DOR phosphorylation at Thr-161 to attenuate morphine antinociceptive tolerance during pain management.
Positive_regulation (targeting) of Phosphorylation (phosphorylation) of Thr-161 associated with pain management, tolerance, opioid receptor, antinociceptive and morphine
15) Confidence 0.02 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0.10 Pain Relevance 1.87
Phosphorylation at Thr-161 is required for normal cell surface expression of DOR, and the formation of DOR-MOR heterodimers.
Positive_regulation (required) of Phosphorylation (Phosphorylation) of Thr-161 associated with opioid receptor
16) Confidence 0.02 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.63

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