INT14397

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Context Info
Confidence 0.46
First Reported 1980
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 14.54
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinc1) extracellular region (Serpinc1)
Anatomy Link Frequency
plasma 3
platelet 3
body 2
macrophages 1
foramen ovale 1
Serpinc1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 40 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
antagonist 7 99.14 Very High Very High Very High
aspirin 11 98.96 Very High Very High Very High
mu opioid receptor 1 98.76 Very High Very High Very High
headache 3 97.36 Very High Very High Very High
anesthesia 14 97.28 Very High Very High Very High
imagery 3 97.28 Very High Very High Very High
Angina 17 95.96 Very High Very High Very High
narcan 4 92.88 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 7 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 2 100.00 Very High Very High Very High
Acute Coronary Syndrome 4 99.84 Very High Very High Very High
Thrombosis 106 99.12 Very High Very High Very High
Thrombosis Related Under Development 14 98.44 Very High Very High Very High
Myocardial Infarction 55 98.00 Very High Very High Very High
Thyroid Neoplasm 1 97.60 Very High Very High Very High
Headache 4 97.36 Very High Very High Very High
Injury 28 97.20 Very High Very High Very High
Convulsion 1 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, preeclamptic women have more pronounced deficiencies of PC, PS, ATIII and more APC resistance compared to normal pregnant women.
Gene_expression (resistance) of ATIII
1) Confidence 0.46 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.17 Pain Relevance 0
These data show that thrombin generation is an important pathogenetic factor and suggest that coronary thrombosis is involved in myocardial infarction in atherosclerotic mice.
Gene_expression (generation) of thrombin associated with atherosclerosis, thrombosis related under development and myocardial infarction
2) Confidence 0.43 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15031124 Disease Relevance 1.94 Pain Relevance 0.22
Anti-thrombin and anti-factor Xa activities of fucoidan
Gene_expression (activities) of Anti-thrombin
3) Confidence 0.33 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.13 Pain Relevance 0
Serial determinations of total FDP, FDP D-Dimer (specific for FbDP), fibrinogen (Fg), PT, APTT, reptilase time (RT), plasminogen, alpha 2-antiplasmin (AAP), euglobulin lysis time (ELT) and antithrombin III (ATIII) were performed before and 1, 2, 4, 6, 12, 24, 48 hr after initiation of tPA injection in the 29 patients in order to evaluate the hemostatic changes after thrombolytic therapy.
Gene_expression (determinations) of ATIII
4) Confidence 0.30 Published 1990 Journal Thromb. Res. Section Abstract Doc Link 1693793 Disease Relevance 0.26 Pain Relevance 0.10
Serial determinations of total FDP, FDP D-Dimer (specific for FbDP), fibrinogen (Fg), PT, APTT, reptilase time (RT), plasminogen, alpha 2-antiplasmin (AAP), euglobulin lysis time (ELT) and antithrombin III (ATIII) were performed before and 1, 2, 4, 6, 12, 24, 48 hr after initiation of tPA injection in the 29 patients in order to evaluate the hemostatic changes after thrombolytic therapy.
Gene_expression (determinations) of antithrombin III
5) Confidence 0.30 Published 1990 Journal Thromb. Res. Section Abstract Doc Link 1693793 Disease Relevance 0.26 Pain Relevance 0.10
Similarly, at 6 weeks after admission, plasma levels of ATIII were still significantly higher than at baseline in controls (p < 0.05), but not in atorvastatin-treated group.
Gene_expression (levels) of ATIII in plasma
6) Confidence 0.20 Published 2006 Journal Int. J. Cardiol. Section Body Doc Link 16337041 Disease Relevance 0.07 Pain Relevance 0
[Antithrombin therapy in acute coronary syndromes].
Gene_expression (therapy) of Antithrombin associated with acute coronary syndrome
7) Confidence 0.17 Published 1994 Journal Cardiologia Section Title Doc Link 7634317 Disease Relevance 0.85 Pain Relevance 0.06
METHODS: In 46 Perthes patients (35 male, 11 female), family history of thrombotic events was investigated, Protein C (PC), free-Protein S (f-PS), antithrombin (AT) activities, fibrinogen level, and resistance to activated Protein C (APC) were measured.
Gene_expression (measured) of antithrombin
8) Confidence 0.16 Published 2005 Journal Pediatr Int Section Body Doc Link 15693865 Disease Relevance 0.09 Pain Relevance 0
The induction chemotherapy included L-asparaginase which causes deficiencies of antithrombin, plasminogen, fibrinogen, and factors IX and XI.
Gene_expression (deficiencies) of antithrombin
9) Confidence 0.09 Published 1980 Journal Cancer Section Abstract Doc Link 6932253 Disease Relevance 1.06 Pain Relevance 0.19
Serine proteases such as thrombin, trypsin and mast cell tryptase can act on different cell types through protease-activated receptors (PARs).
Gene_expression (proteases) of thrombin in mast cell
10) Confidence 0.08 Published 2009 Journal Pain Section Abstract Doc Link 19674841 Disease Relevance 0.37 Pain Relevance 0.31
CONCLUSIONS: Patients with unstable coronary syndromes had increased levels of IL-6, sVCAM-1 and vWF as well as decreased levels of ATIII and PrtC by their admission.
Gene_expression (levels) of ATIII
11) Confidence 0.07 Published 2007 Journal Int. J. Cardiol. Section Body Doc Link 16787670 Disease Relevance 0.17 Pain Relevance 0
We examined the effects of methylnaltrexone (MNTX), a mu opioid receptor (mOP-R) antagonist, on human pulmonary EC barrier disruption produced by edemagenic agents including morphine, the endogenous mOP-R agonist DAMGO, thrombin, and LPS.
Gene_expression (produced) of thrombin associated with antagonist, agonist, mu opioid receptor and morphine
12) Confidence 0.06 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17395891 Disease Relevance 0.53 Pain Relevance 0.57
A complete coagulation profile, including thrombin time, platelet count, protein C, protein S, antithrombin III, homocysteine level, factor V Leiden mutation, plasminogen, and prothrombin G20210A mutation, was obtained in patients diagnosed with superior mesenteric vein thrombosis.
Gene_expression (time) of antithrombin in superior mesenteric vein
13) Confidence 0.06 Published 2003 Journal Dis. Colon Rectum Section Body Doc Link 12792441 Disease Relevance 0.16 Pain Relevance 0
Within hypotensive study groups, postoperative fibrinogen levels were significantly different, whereas intraoperative platelet aggregability, postoperative platelet count, prothrombin time, activated partial thromboplastin time and antithrombin levels were not different.
Gene_expression (levels) of antithrombin in platelet associated with hypotension
14) Confidence 0.06 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11672580 Disease Relevance 0.92 Pain Relevance 0.60
Coagulation studies showed decreased levels of fibrinogen, antithrombin-III and plasminogen.
Gene_expression (levels) of antithrombin-III
15) Confidence 0.05 Published 1989 Journal Rinsho Ketsueki Section Abstract Doc Link 2601047 Disease Relevance 0.34 Pain Relevance 0.14
Hematologic investigations (APTT, PT, INR, Cardiolipin antibody, C-reactive protein, Lupant anticoagulant, Factor V Leiden, Antithrombin, ANA, Protein C, Protein S, and RPR) were obtained three months post injury.
Gene_expression (antibody) of Antithrombin associated with injury
16) Confidence 0.05 Published 2004 Journal Thromb J Section Body Doc Link PMC526763 Disease Relevance 0.32 Pain Relevance 0.08
No differences were apparent between the two samples when spread on fibrinogen ± thrombin or collagen indicating that cortactin distribution is normal in these cells.
Gene_expression (spread) of thrombin
17) Confidence 0.05 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.27 Pain Relevance 0
Quantitative levels of cTnT and plasma concentrations of fibrin monomers (FM), prothrombin fragments F1+2, thrombin antithrombin III complexes (TAT), plasminogen and alpha2-antiplasmin were sampled serially within the first 48 h.
Gene_expression (levels) of antithrombin in plasma
18) Confidence 0.04 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 10739377 Disease Relevance 0.34 Pain Relevance 0.39
Coagulation parameters such as prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen concentration, platelet count, fibrin monomers, D-dimers, antithrombin III and factor XIII activities, thrombelastography, and platelet aggregometry were measured during a 4-h period after sequential double endotoxin administration (80 and 40 micrograms/kg of body weight, intravenously).
Gene_expression (activities) of antithrombin in body associated with body weight
19) Confidence 0.04 Published 1995 Journal Lab. Anim. Sci. Section Abstract Doc Link 8569153 Disease Relevance 0.33 Pain Relevance 0.09
Tests included the following: one-stage prothrombin ratio; activated partial thromboplastin time; fibrinogen and fibrin degradation products; thrombin time; plasma fibrinogen level; antithrombin III and activated clotting time.
Gene_expression (products) of antithrombin in plasma associated with coagulation disorder
20) Confidence 0.04 Published 1991 Journal Crit. Care Med. Section Abstract Doc Link 1884620 Disease Relevance 0.34 Pain Relevance 0.08

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