INT143983

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.26
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lifr) plasma membrane (Lifr)
Anatomy Link Frequency
synovial fluid 1
fat 1
liver 1
ciliary 1
Lifr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 73 99.98 Very High Very High Very High
psoriasis 1 98.96 Very High Very High Very High
rheumatoid arthritis 76 98.88 Very High Very High Very High
Arthritis 3 98.36 Very High Very High Very High
spinal inflammation 1 97.52 Very High Very High Very High
antagonist 3 95.68 Very High Very High Very High
Inflammation 9 93.28 High High
Infliximab 32 92.84 High High
Paracetamol 4 91.00 High High
Etanercept 1 85.96 High High
Disease Link Frequency Relevance Heat
Leukemia 10 100.00 Very High Very High Very High
Psoriasis 1 98.96 Very High Very High Very High
Rheumatoid Arthritis 77 98.88 Very High Very High Very High
Aging 252 98.76 Very High Very High Very High
Seronegative Spondarthritis 1 98.36 Very High Very High Very High
Liver Disease 4 98.32 Very High Very High Very High
Low Back Pain 1 97.52 Very High Very High Very High
Infection 1 96.80 Very High Very High Very High
Stress 24 96.08 Very High Very High Very High
Lifespan 188 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While there are several molecules that Lifr may interact with [41-43], Lifr expression is a primary determinant of cellular responsiveness to leukemia inhibitory factor (Lif) [44].
Gene_expression (expression) of Lifr associated with leukemia
1) Confidence 0.47 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.90 Pain Relevance 0.04
Declines in Lifr expression may increase sensitivity to drug-induced liver disease [49], which in general is contrary to the stress resistance characteristics of long-lived mice [11], but is consistent with one study that found decreased resistance to acetaminophen toxicity in multiple dwarf strains [50].
Gene_expression (expression) of Lifr in liver associated with stress, liver disease, toxicity, paracetamol and sprains and strains
2) Confidence 0.47 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.83 Pain Relevance 0.17
Lifr expression was downregulated at all ages in four long-lived dwarf models, by short-term CR and by low-fat diet.
Gene_expression (expression) of Lifr in fat
3) Confidence 0.47 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.88 Pain Relevance 0.03
Of genes differentially expressed in all four long-lived models, only three were also differentially expressed with respect to at least one CR contrast (Igf1, Igfals and Lifr) (Fig. 6).
Gene_expression (expressed) of Lifr
4) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 1.01 Pain Relevance 0
IL-6 family cytokines consist of IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CP-1).
Gene_expression (consist) of leukemia inhibitory factor in ciliary associated with leukemia and cytokine
5) Confidence 0.41 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.22 Pain Relevance 0.74
RA synoviocytes produce higher levels of OPG than do peripheral blood mononuclear cells or synovial fluid mononuclear cells, but they do not produce soluble receptor activator of nuclear factor-?
Neg (not) Gene_expression (produce) of soluble receptor in synovial fluid associated with rheumatoid arthritis
6) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.47 Pain Relevance 0.38
To be able to study the effects of the soluble receptor fusion protein in mouse models, including those that mimic human granulomatous infections, a murine soluble p75-TNF receptor-murine IgG1 (murine p75-murine IgG1) fusion protein had to be constructed.
Gene_expression (effects) of soluble receptor associated with infection
7) Confidence 0.05 Published 2007 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 17502870 Disease Relevance 0.95 Pain Relevance 0.38
The expression of the ApoER2 variant containing the furin consensus site results in the production of soluble receptor consisting of the ligand binding domain [152].
Gene_expression (production) of soluble receptor
8) Confidence 0.01 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.04
However, a dominant negative effect has been attributed to the processing of ApoER2 and subsequent production of soluble receptor.
Gene_expression (production) of soluble receptor
9) Confidence 0.01 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0

General Comments

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