INT143991

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.54
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prdx2) mitochondrion (Prdx2) oxidoreductase activity (Prdx2)
molecular_function (Prdx2) cytoplasm (Prdx2)
Anatomy Link Frequency
bladder 2
beta cells 1
Prdx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 1 92.88 High High
Bioavailability 3 92.48 High High
Hippocampus 3 86.16 High High
Central nervous system 6 72.80 Quite High
Inflammation 6 16.00 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 1 95.00 High High
Hyperlipidemia 1 94.56 High High
Myocardial Infarction 1 93.92 High High
Cv General 3 Under Development 1 92.88 High High
Overactive Bladder 33 92.72 High High
Nervous System Injury 6 84.40 Quite High
Lower Urinary Tract Symptoms 18 76.28 Quite High
Benign Prostatic Hypertrophy 24 70.48 Quite High
Diabetes Mellitus 3 65.04 Quite High
Insulin Resistance 1 60.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we have investigated the role of P-glycoprotein (P-gp) in the intestinal absorption of tanshinone IIA (TSA), a major active constituent of Danshen, using several in vitro and in vivo models.
Gene_expression (absorption) of TSA
1) Confidence 0.61 Published 2007 Journal Curr. Drug Metab. Section Abstract Doc Link 17504222 Disease Relevance 0.38 Pain Relevance 0.14
Similarly; increased expression of glycolytic enzymes and ER proteins was found in the highly glucose sensitive beta cells, as well as increased expression of several peroxiredoxins (Prdx3, Prdx5 and to a lesser extent Prdx1 and Prdx2) and down-regulated level of secretory granule-associated proteins (Vamp2, Chga, Scg3).
Gene_expression (expression) of Prdx2 in beta cells
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0.18 Pain Relevance 0
In this study, we detected the over-expression of three proteins (OPTN, thioredoxin and preprohaptoglobin), and the under-expression of four proteins (peroxiredoxin 2, transgelin [SM22 alpha], HCNP, and beta-galactoside-binding lectin).
Gene_expression (expression) of peroxiredoxin 2
3) Confidence 0.16 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.31 Pain Relevance 0.08
Four proteins (peroxiredoxin 2, transgelin [SM22 alpha], hippocampal cholinergic neurostimulating peptide [HCNP] and beta-galactoside-binding lectin) were under-expressed in the obstructed bladder.
Gene_expression (expressed) of peroxiredoxin 2 in bladder
4) Confidence 0.16 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.34 Pain Relevance 0
In addition, four proteins, such as peroxiredoxin 2, transgelin, hippocampal cholinergic neurostimulating peptide (HCNP) and beta-galactoside-binding lectin, were under-expressed in the bladder of BOO group.
Gene_expression (expressed) of peroxiredoxin 2 in bladder
5) Confidence 0.16 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2779299 Disease Relevance 0.33 Pain Relevance 0

General Comments

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